Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (3): 374-390.DOI: 10.19894/j.issn.1000-0518.210108

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Application of Biosensors Based on Aptamers and Antibodies in the Detection of Estradiol

Tao WANG1,2, Sha LIU2, Bao-Lin LIU1(), Zhi-Xian GAO2()   

  1. 1.School of Medical Devices and Food,University of Shanghai for Science and Technology,Shanghai 200093,China
    2.Institute of Environmental Medicine and Operational Medicine,Academy of Military Medicine,Academy of Military Sciences,Tianjin Key Laboratory of Environmental and Food Safety Risk Monitoring Technology,Tianjin 300050,China
  • Received:2021-03-11 Accepted:2021-06-26 Published:2022-03-01 Online:2022-03-15
  • Contact: Bao-Lin LIU,Zhi-Xian GAO
  • About
  • Supported by:
    the National Natural Science Foundation of China(81773482)


Estradiol (E2) is one of the major environmental estrogens, which has the characteristics of strong action and extensive harmness, and can disrupt the normal endocrine function of human and animal bodies, thus causing adverse effects. Therefore, the rapid and accurate detection of E2 is of great importance for food safety and public health. Traditional detection methods are mainly based on large-scale instrument analysis. These methods have high sensitivity and accuracy, but also have drawbacks such as tedious operation, high cost and limitation to laboratory. In recent years, researchers have developed a variety of biosensors to detect E2. In the early stage, there will be problems such as low sensitivity and interference signals. There is a lot of room for improvement. Gradually, a new method with simple operation, high detection sensitivity and rapid on-site detection can be explored. Based on a brief introduction to the characteristics of aptamers and antibodies, this article summarizes the latest research progress in E2 detection of various biosensors using aptamers and antibodies as recognition signals. Finally, this review provides new prospects for its research direction.

Key words: Estradiol detection, Aptamer, Antibody, Biosensor

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