Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (11): 1249-1261.DOI: 10.11944/j.issn.1000-0518.2020.11.200153

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Research on the Enhanced Activity of Hemin/G-Quadruplex DNAzyme and Its Application in Biosensors

MO Yanhonga,b, LI Huib, WANG Binb, XU Xiaohuib, LIU Sisib, ZENG Dongdongb*   

  1. aSchool of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;
    bShanghai University of Medicine & Health Sciences,Shanghai 201318,China
  • Received:2020-05-21 Revised:2020-06-19 Accepted:2020-07-08 Published:2020-11-01 Online:2020-11-04
  • Contact: ZENG Dongdong, associate professor; Tel:021-65883150; Fax:021-65881737;; Research interests:nanomaterials and biosensors
  • Supported by:
    Supported by Shanghai Natural Science Foundation(No.19ZR1474300) and Shanghai Key Laboratory of Molecular Imaging Project(No.18DZ2260400)

Abstract: Hemin/G-quadruplex DNAzyme is a type of DNA molecule with peroxidase-like activity. Because of its excellent activity, easy modification and programmability, it has been widely used in biosensors and other fields. This article first briefly introduces the structure of G-quadruplex, and then reviews the strategies for enhancing hemin/G-quadruplex DNAzyme activity and application of biosensors based on hemin/G-quadruplex DNAzyme in the detection of biomarkers, microorganisms, biotoxins and metal ions. We also prospect the development trend of hemin/G-quadruplex DNAzyme.

Key words: hemin/G-quadruplex, dnazyme, peroxidase, biosensor

CLC Number: