Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (9): 1107-1112.DOI: 10.11944/j.issn.1000-0518.2018.09.180170

• Review • Previous Articles     Next Articles

Electrochemiluminescent Biosensing and Its Application in Rapid Detection of Acute Myocardial Infarction Markers

QIN Xiaoli,WANG Minghan,DONG Yifan,SHAO Yuanhua()   

  1. Institute of Analytical Chemistry at College of Chemistry and Molecular Engineering,Beijing National Research Center for Molecular Sciences,Peking University,Beijing 100871,China
  • Received:2018-05-14 Accepted:2018-05-22 Published:2018-09-01 Online:2018-08-06
  • Contact: SHAO Yuanhua
  • Supported by:
    Supported by National Key Research and Development Program of China(No.2016YFA0201300), National Natural Science Foundation of China(No.21335001, No.21575006), China Postdoctoral Science Foundation(No.2016M600846)


Design and development of simple, ultrasensitive, and high selective analytical techniques and methods for the clinical diagnosis and monitoring of a series of acute myocardial infarction(AMI) markers are urgently required for complicated sample matrix. Due to its good stability, high sensitivity, wide linear range, and good controllability, electrochemiluminescent(ECL) analysis technique is commonly used for low-level analytes. Combined with biosensing, it shows great promise in assaying low-level AMI biomarkers in complicated matrix such as biological fluids. This review presents the development of ECL sensing technique for AMI bioanalysis in recent five years. Some ECL probes, co-reactants, multianalyte biosensing methods and their application in AMI marker analysis have been introduced.

Key words: electrochemiluminescence, biosensor, electrochemiluminescence probes, array, acute myocardial infarction markers analysis