Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (4): 367-378.DOI: 10.11944/j.issn.1000-0518.2019.04.180412

• Review • Previous Articles     Next Articles

Recent Advances of Liquid Biopsy for Bladder Cancer Diagnosing

ZENG Boa,YANG Yanbinga,LIANG Lingb,YUAN Quana*()   

  1. aCollege of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China
    bMolecular Science and Biomedicine Laboratory(MBL),Institute of Chemical Biology and Nanomedicine,College of Chemistry and Chemical Engineering, Hunan University,Changsha 410082,China
  • Received:2018-12-27 Accepted:2019-02-03 Published:2019-04-01 Online:2019-04-02
  • Contact: YUAN Quan
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21675120), the National Key Research and Development Program of China(No.2017YFA0208000), the Foundation for Innovative Research Groups of NSFC(No.21521063),


Bladder cancer is a kind of malignant tumor with high morbidity and mortality. Usually, it only can be diagnosed at the middle or late stage, causing serious physical and mental harm to patients. Cystoscopy is the gold standard for the diagnosis of bladder cancer. However, cystoscopy is invasive to some extent. The limited sensitivity and specificity of cystoscopy are also main barriers for achieving the required early and precise diagnosis of bladder cancer. The occurrence of bladder cancer would have a significant impact on the components of blood and urine. In this regard, non-invasive liquid biopsy shows great potential for realizing early bladder cancer diagnosis. This review describes the development of liquid biopsy-based diagnostic methods for bladder cancer. The main biomarkers of bladder cancer are briefly introduced. The diagnostic methods and mechanisms of bladder cancer with liquid(such as urine and blood) as the detection objects are comprehensively discussed. In addition, the opportunities and challenges of liquid biopsy for bladder cancer diagnosis are recommended. We hope this review will provide guidance for bladder cancer-based liquid biopsy techniques.

Key words: bladder cancer diagnosis, liquid biopsy, ultraviolet-visible absorption spectrum, fluorescence spectrum, electrochemiluminescence, electrochemical sensing