Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (3): 480-488.DOI: 10.19894/j.issn.1000-0518.210180

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Facile One⁃Step Synthesis of WS2@Au Quantum Dot Composite by in situ Reduction and Its Sensing Application

Hong-Zhen PENG1,3,4, Yu ZHANG1,3, Lin-Jie GUO1,3, Wei SONG2(), Qing-Nuan LI1(), Xiang-Ying MENG2()   

  1. 1.Division of Physical Biology,CAS Key Laboratory of Interfacial Physics and Technology,Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China
    2.School of Medical Laboratory,Weifang Medical University,Weifang 261053,China
    3.The Interdisciplinary Research Center,Shanghai Synchrotron Radiation Facility,Zhangjiang Laboratory,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201210,China
    4.University of Chinese Academy of Sciences,Beijing 100049,China
  • Received:2021-04-10 Accepted:2021-07-15 Published:2022-03-01 Online:2022-03-15
  • Contact: Wei SONG,Qing-Nuan LI,Xiang-Ying MENG
  • About
  • Supported by:
    the Medical and Health Science and Technology Development Program of Shandong Province(202012060616);the Natural Science Foundation of Shandong Province(ZR2016BL19)


The interface modification of electrochemical sensors is an important way to improve their detection performance. Among them, enhancing the biocompatibility and electrical conductivity of the electrochemical sensing interface is a major challenge for the development of electrochemical sensors. In this work, the surface of glassy carbon electrode is functionalized based on WS2@Au quantum dots (WS2@Au QDs) prepared by in situ one-step reduction, which is used to immobilize oxidoreductase, thus realizing the construction of high-performance biosensors. By virtue of the excellent biocompatibility and electrical conductivity of WS2@Au QDs, the WS2@Au QDs can effectively protect the catalytic activity of GOx and promote the direct electron transfer between GOx and the electrode, and the electron transfer rate constant reaches 2.25 s-1. Based on the good electrocatalytic effect of the sensor on glucose, the method has been successfully applied to the detection of glucose, with a linear range of 5~50 μmol/L and a detection limit of 1.5 μmol/L, and the sensor shows good selectivity, reproducibility and stability. These results suggest that the WS2@Au QDs has potential important application prospects in the interface modification of biosensors, which lays a good research foundation for the construction of high-performance biosensors.

Key words: WS2@Au quantum dots, In situ reduction, Direct electrochemistry, Glucose oxidase, Biosensor

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