Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (10): 1155-1165.DOI: 10.11944/j.issn.1000-0518.2018.10.170461

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Research Progress on Cell Imaging Based on the Aggregation-induced Emission Fluorescent Probes

WANG Taoa,MA Lamaocaob,MA Hengchanga*()   

  1. aKey Laboratory of Polymer Materials of Gansu Province
    Key Laboratory of Macromolecule Materials,Ministry of Education,College of Chemistry and Chemical Engineering
    bShaw Library,Northwest Normal University,Lanzhou 730070,China
  • Received:2017-12-21 Accepted:2018-04-25 Published:2018-10-01 Online:2018-10-09
  • Contact: MA Hengchang
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21764012)


Fluorescent probes as a major discovery in the field of chemical sensing at the end of the 20th century have the advantages of simple synthesis, high sensitivity, good selectivity, short response time and high visualization. The combination of the fluorescent group with the aggregation-induced emission(AIE) characteristics and the biocompatible polymer makes the fluorescent materials have the characteristics of low toxicity, good light stability and good biocompatibility. In molecular, ion detection and cell imaging technology it has been widely studied and applied. This review summarizes the fluorescence probes for cytoplasmic imaging, cell membrane imaging, mitochondrial imaging, lysosomal imaging, lipid droplet imaging, nuclear imaging, nuclear and mitochondrial dual-targeting imaging and the prospects for their application.

Key words: fluorescence probe, chemical sensing, biological imaging, aggregation-induced emission