Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (1): 1-20.DOI: 10.11944/j.issn.1000-0518.2018.01.170328

• Review • Previous Articles     Next Articles

Advanced in Fluorescent Probes Based on Excited State Intramolecular Proton Transfer

WANG Dejia,XU Yongqian(),SUN Shiguo,LI Hongjuan   

  1. Shaanxi Key Laboratory of Natural Products & Chemical Biology,College of Chemistry & Pharmacy,Northwest A & F University,Yangling,Shaanxi 712100,China
  • Received:2017-09-11 Accepted:2017-09-28 Published:2018-01-03 Online:2018-01-03
  • Contact: XU Yongqian
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21676218, No.21476185,21472016, No.21272030)


Fluorescent probes are gaining more and more attention because of their high selectivity, sensitivity, fast response, simple operation and low detection limit. Compounds based on excited state intramolecular proton transfer(ESIPT) have special excited state photophysical properties, such as high fluorescence quantum yield and large Stokes shift. For fluorescent molecules, the larger Stokes shift can reduce the interference caused by self-absorption and internal filtration, and enhance light-fastness of the molecules and facilitate the emitting of fluorescence. In this review, we summarized these ESIPT fluorescent probes from the classification of targets. The targets for detection were divided into ions(including metal cations and anions), neutral small molecules and biological macromolecules. The existing problems and application prospects of fluorescent molecules based on ESIPT were commented.

Key words: sexcited state intramolecular proton transfer, metal cations, anions, neutral small molecule, biological macromolecule, fluorescence probes