Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (12): 1433-1449.DOI: 10.11944/j.issn.1000-0518.2017.12.170327

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Research Progress on Application of Fluorescent Sensors Based on Squaraine Dyes

SHI Weining,XU Yongqian(),SUN Shiguo,LI Hongjuan   

  1. Shaanxi Key Laboratory of Natural Products & Chemical Biology,College of Chemistry &Pharmacy,Northwest A&F University,Yangling,Shaanxi 712100,China
  • Received:2017-09-11 Accepted:2017-09-30 Published:2017-12-04 Online:2017-12-04
  • Contact: XU Yongqian
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21676218, No.21476185, No.21472016, No.21272030)


Due to the unique D-A-D conjugate structure, squaraine dyes possess strong absorption and fluorescence emission in the visible and near infrared regions. As the fluorophore of near infrared fluorescent probes, it has been applied for detection of proteins, amino acids and small biological molecules in vivo, environmental pollutants and so on. In this paper, we reviewed the application of squaraine dyes in the detection of proteins, amino acids, small molecules, cations and other substances according to the work of our group in these years.

Key words: squaraine dye, near infrared fluorescence probes, bioassay, aggregation-deaggregation