Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (8): 986-994.DOI: 10.19894/j.issn.1000-0518.210151

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Synthesis and Application of a Fluorescence Probe with Quinazolinone as the Core Block for Highly Selective and Sensitive Detection of Hypochlorite Ion

ZHANG Cheng-Lu*, BAO Jin-Di, YU Feng-Ming, DONG Wen-Jing, ZHANG Yang, GONG Rong-Qing, ZHANG Yan-Peng, ZHANG Lu   

  1. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China
  • Received:2021-03-30 Revised:2021-07-05 Published:2021-08-01 Online:2021-10-01
  • Supported by:
    National Natural Science Foundation of China (No.21641012)

Abstract: For highly selective and targeted fluorescent identification of ClO-, a novel fluorescence molecule (E)-11-oxo-N'-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)-11H-pyrido [2,1-b]quinazole phenoline-6-carbohydrazide (XJQZL) was designed and synthesized, in which the core block tricycloquinazolinone [11H-pyrido[2,1-b]quinazolin-11-one] spliced with quinolinone aldehyde was used as the fluorophore and acylhydrazone as the reaction position. It is found that XJQZL has excellent fluorescence properties: good stability in a wide range of pH, high fluorescence quantum yield (0.469) and large Stokes shift (128 nm). XJQZL exhibits highly selective fluorescent recognition of ClO- within 30 s. The detection limit and sensitivity are 1×10-7 mol/L and 1.23×105 L/mol, respectively. The fluorescent detection of ClO- using XJQZL can be in a wide range of pH (pH=5~13). XJQZL has a high quenching efficiency of 81.6% and strong anti-interference. XJQZL can be applied to qualitatively and quantitatively confirm ClO- in actual water samples.

Key words: Quinazolinone, Quinolinone aldehyde, Fluorescence probe, Hypochlorite

CLC Number: