A Coumarin Based Ratiometric Fluorescent Probe for Fast Sensing of Hypochlorite

doi:10.11944/j.issn.1000-0518.2017.12.170311

Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (12): 1457-1461.DOI: 10.11944/j.issn.1000-0518.2017.12.170311

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A Coumarin Based Ratiometric Fluorescent Probe for Fast Sensing of Hypochlorite

ZHANG Weijie^a,HUO Fangjun^b,YIN Caixia^a^*()

^aKey Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science
^bResearch Institute of Applied Chemistry,Shanxi University,Taiyuan 030006, China

Received:2017-09-01 Accepted:2017-10-11 Published:2017-12-04 Online:2017-12-04
Contact: YIN Caixia
Supported by:
Supported by the National Natural Science Foundation of China(No.21672131, No.21775096, No.201705105), the Talents Support Program of Shanxi Province(No.2014404), the Shanxi Province Foundation for Returnee(No.2012-007)

Abstract

Abstract:

Hypochlorous acid(HClO) is one of the biologically important reactive oxygen species(ROS), which plays important roles in the human immune defence system, and contributes to the destruction of invading bacteria and pathogens. Here, a novel ratiometric probe for detection of hypochlorite was designed and developed based on the coumarin. The sensor shows excellent selectivity, high sensitivity(12 nmol/L) and a rapid response(within 5 s) toward hypochlorite, accompanied with an obvious color change from colorless to yellow. Other anions and ROS all triggers very minor changes. Furthermore, the sensing mechanism was confirmed by electrospray ionization-mass spectrometry(ESI-MS) and spectrometry analysis, which was based on the strong oxidized by HClO/ClO^-, then hydrolyzed to generate fluorescent compound.

Key words: coumarin, hypochlorite, fluorescence probe, fast response

ZHANG Weijie, HUO Fangjun, YIN Caixia. A Coumarin Based Ratiometric Fluorescent Probe for Fast Sensing of Hypochlorite[J]. Chinese Journal of Applied Chemistry, 2017, 34(12): 1457-1461.

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A Coumarin Based Ratiometric Fluorescent Probe for Fast Sensing of Hypochlorite

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