Chinese Journal of Applied Chemistry

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Detection of Cefazolin Based on the Plasma Resonance Absorption of Gold Nanoparticles

LI Jingyun, WANG Yi, XU Jiali, LI Yuanfang*   

  1. (Education Ministry Key Laboratory on Luminescence and Real-Time Analysis,College of
    Chemistry and Chemical Engineering,Southwest University,Chongqing 400715)
  • Received:2011-05-30 Revised:2011-08-01 Online:2012-04-10 Published:2012-04-10

Abstract: The cefazolin can be detected according to the change of solution color resulting from the plasmonic resonance absorption of AuNPs. The absorbance ratio at 520/660 nm of AuNPs is proportional to the concentration of cefazolin in the range of 0.1~5.0 μmol/L with the detection limit of 14 nmol/L. This method could be extended to the determination of cefazolin sodium powder injection, the recovery of cefazolin was in the range of 97.4%~100.2% while the relative standard deviation was less than 6.1%.

Key words: Gold nanoparticles, Cefazolin, Sodium chloride, Plasma resonance absorption, Colorimetric determination

CLC Number: