Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (5): 489-499.DOI: 10.11944/j.issn.1000-0518.2019.05.180253

• Review • Previous Articles     Next Articles

Research Progress on Biosensing Based on Peptides and Gold Nanoparticles Composite Materials

LI Xinyi,WANG Xiaohua,ZHOU Xiaodong(),HU Jiming()   

  1. Key Laboratory of Analytical Chemistry for Biology and Medicine,College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430000,China
  • Received:2018-07-28 Accepted:2018-10-12 Published:2019-05-01 Online:2019-05-06
  • Contact: ZHOU Xiaodong,HU Jiming
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21775114, No.81471696)


As the intermediate product of protein hydrolysis, peptides are synthesized through the polymerization of α-amino acids. Given the great biocompatibility and surface plasmon resonance(SPR) of gold nanoparticles(AuNPs), biosensors based on the peptide-AuNPs system have attracted the attention of many scientists. In this review, the biosensing research and application of the peptide-AuNPs complexes are summarized, including the preparation and properties of peptides and AuNPs, the synthesis of peptide-AuNPs and the application in biosensing.

Key words: peptide, the modification of gold nanoparticles, biosensing