Research Progress of the Peptide-Based Self-assembled Nanomaterials Against Microbial Resistance

doi:10.19894/j.issn.1000-0518.210057

Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (5): 546-558.DOI: 10.19894/j.issn.1000-0518.210057

• Review • Previous Articles Next Articles

Research Progress of the Peptide-Based Self-assembled Nanomaterials Against Microbial Resistance

LIU Jiao^1,3, ZOU Peng-Fei^1,3, LI Ping³, ZHANG Xiao¹, WANG Xin-Xin², GAO Yuan-Yuan^1*, LI Li-Li^3*

¹School of Pharmacy, Weifang Medical University, Weifang 261000, China
²School of Life Science and Technology , Weifang Medical University, Weifang 261000, China
³CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100109, China

Received:2021-01-30 Accepted:2021-03-10 Published:2021-05-01 Online:2021-07-01
Supported by:
National Key R&D Program Project (No.2018YFE0205400), the National Natural Science Foundation of China (Nos.51873045, 3160040663, 31600775), the Youth Innovation Promotion, CAS (No.2017053)

Abstract

Abstract: Bacterial infections, especially drug-resistant bacterial infections, are one of the greatest threats to human health. Peptides play an important role in the treatment of drug-resistant bacterial infections due to their good biocompatibility and a mechanism significantly less prone to inducing resistance. Among them, the biomimetic nanostructures prepared from peptide self-assembled nanomaterials show unique advantages in resisting infections by resistant-bacteria. Nowadays, peptide self-assembled nanomaterials have been used in the treatment of drug-resistant bacterial infections. For example, they often target at cell membranes where bacterias are less likely to develop resistance. In addition, peptide self-assembled nanomaterials have a good advantage of acting on bacterial biofilms and treating intractable bacterial infections because of their unique particle size and biological characteristics. Therefore, it is of great significance to fight against drug-resistant bacterial infections with peptide self-assembled nanomaterials consisted of different components. In this review, the secondary structure of peptides and the main nanostructures formed by peptide self-assembly were summarized. What′s more, the strategies of peptide self-assembled nanomaterials against drug-resistant bacteria were demonstrated. Finally, the prospects and remaining challenges of peptide self-assembled nanomaterials as antibacterial agents in clinical applications were introduced. Therefore, we hope to provide some references for their further applications by this minireview.

Key words: Peptide, Self-assembly, Nanomaterials, Resistance to drug-resistant bacteria

CLC Number:

O631

LIU Jiao, ZOU Peng-Fei, LI Ping, ZHANG Xiao, WANG Xin-Xin, GAO Yuan-Yuan, LI Li-Li. Research Progress of the Peptide-Based Self-assembled Nanomaterials Against Microbial Resistance[J]. Chinese Journal of Applied Chemistry, 2021, 38(5): 546-558.

References

[1] HAMPTON T. Report reveals scope of US antibiotic resistance threat[J]. J Am Med Assoc, 2013, 310(16): 1661-1663.
[2] MAKABENTA J M V, NABAQY A, LI C H, et al. Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections[J]. Nat Rev Microbiol, 2021, 19(1): 23-36.
[3] LEBEAUX D, CHAUHAN A, RENDUELES O, et al. From in vitro to in vivo models of bacterial biofilm-related infections[J]. Pathogens, 2013, 2(2): 288-356.
[4] SONG J, JANG J. Antimicrobial polymer nanostructures: synthetic route, mechanism of action and perspective[J]. Adv Colloid Interface Sci, 2014, 203: 37-50.
[5] 孙振龙, 闫顺杰, 周容涛, 等. 基于抗菌肽的智能型抗菌涂层研究进展[J]. 应用化学, 2020, 37(8): 865-876.
SUN Z L, YAN S J, ZHOU R T, et al. Recent progress in the development of smart coatings based on antimicrobial peptides[J]. Chinese J Appl Chem, 2020, 37(8): 865-876.
[6] GLINEL K, THEBAULT P, HUMBLOT V, et al. Antibacterial surfaces developed from bio-inspired approaches[J]. Acta Biomater, 2012, 8(5): 1670-1684.
[7] ONG Z Y, WIRADHARMA N, YANG Y Y. Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials[J]. Adv Drug Deliv Rev, 2014, 78: 28-45.
[8] WHITESIDES G M, GRZYBOWSKI B. Self-assembly at all scales[J]. Science, 2002, 295(5564): 2418-2421.
[9] ULIJN R V, SMITH A M. Designing peptide based nanomaterials[J]. Chem Soc Rev, 2008, 37(4): 664-675.
[10] WANG Y, XU H, ZHANG X. Tuning the amphiphilicity of building blocks: controlled self-assembly and disassembly for functional supramolecular materials[J]. Adv Mater, 2009, 21(28): 2849-2864.
[11] UMERSKA A, CASSISA V, BASTIAT G, et al. Synergistic interactions between antimicrobial peptides derived from plectasin and lipid nanocapsules containing monolaurin as a cosurfactant against Staphylococcus aureus[J]. Int J Nanomedicine, 2017, 12: 5687-5699.
[12] LI L L, AN H W, PENG B, et al. Self-assembled nanomaterials: design principles, the nanostructural effect, and their functional mechanisms as antimicrobial or detection agents[J]. Mater Horizons, 2019, 6(9): 1794-1811.
[13] DI Y P. Antimicrobial peptides in host defense against drug-resistant bacterial and viral infections[J]. Curr Med Chem, 2020, 27(9): 1385-1386.
[14] WAGHU F H, GOPI L, BARAI R S, et al. CAMP: collection of sequences and structures of antimicrobial peptides[J]. Nucleic Acids Res, 2014, 42(D1): D1154-D1158.
[15] DING X K, DUAN S, DING X J, et al. Versatile antibacterial materials: an emerging arsenal for combatting bacterial pathogens[J]. Adv Funct Mater, 2018, 28(40): 1802140.
[16] ZOU P, CHEN W T, SUN T, et al. Recent advances: peptides and self-assembled peptide-nanosystems for antimicrobial therapy and diagnosis[J]. Biomater Sci, 2020, 8(18): 4975-4996.
[17] LEIGH T, FERNANDEZ-TRILLO P. Helical polymers for biological and medical applications[J]. Nat Rev Chem, 2020, 4(6): 291-310.
[18] XIONG M, LEE M W, MANSBACH R A, et al. Helical antimicrobial polypeptides with radial amphiphilicity[J]. PNAS, 2015, 112(43): 13155-13160.
[19] BROGDEN K A. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?[J]. Nat Rev Microbiol, 2005, 3(3): 238-250.
[20] JIANG Z, VASIL A I, HALE J D, et al. Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides[J]. Biopolymers, 2008, 90(3): 369-383.
[21] WEHKAMP J, FELLERMANN K, HERRLINGER K R, et al. Mechanisms of disease: defensins in gastrointestinal diseases[J]. Nat Clin Pract Gastroenterol Hepatol, 2005, 2(9): 406-415.
[22] SHARMA H, NAGARAJ R. Antimicrobial activity of human beta-defensin 4 analogs: insights into the role of disulfide linkages in modulating activity[J]. Peptides, 2012, 38(2): 255-265.
[23] MOHAMED M F, ABDELKHALEK A, SELEEM M N. Evaluation of short synthetic antimicrobial peptides for treatment of drug-resistant and intracellular Staphylococcus aureus[J]. Sci Rep, 2016, 6: 29707.
[24] CHOW H Y, ZHANG Y, MATHESON E, et al. Ligation technologies for the synthesis of cyclic peptides[J]. Chem Rev, 2019, 119(17): 9971-10001.
[25] RASHAD A A. Click chemistry for cyclic peptide drug design[J]. Methods Mol Biol, 2019, 2001: 133-145.
[26] RIAHIFARD N, MOZAFFARI S, ALDAKHIL T, et al. Design, synthesis, and evaluation of amphiphilic cyclic and linear peptides composed of hydrophobic and positively-charged amino acids as antibacterial agents[J]. Molecules, 2018, 23(10): 2722.
[27] STRIEKER M, TANOVIC A, MARAHIEL M A. Nonribosomal peptide synthetases: structures and dynamics[J]. Curr Opin Struct Biol, 2010, 20(2): 234-240.
[28] GAUDELLI N M, LONG D H, TOWNSEND C A. β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis[J]. Nature, 2015, 520(7547): 383-387.
[29] LIU Y, DING S, SHEN J, et al. Nonribosomal antibacterial peptides that target multidrug-resistant bacteria[J]. Nat Prod Rep, 2019, 36(4): 573-592.
[30] CHAKRABORTY P, GAZIT E. Amino acid based self-assembled nanostructures: complex structures from remarkably simple building blocks[J]. Chem Nano Mat, 2018, 4(8): 730-740.
[31] UCHIDA M, KLEM M T, ALLEN M, et al. Biological containers: protein cages as multifunctional nanoplatforms[J]. Adv Mater, 2007, 19(8): 1025-1042.
[32] CAVALLI S, ALBERICIO F, KROS A. Amphiphilic peptides and their cross-disciplinary role as building blocks for nanoscience[J]. Chem Soc Rev, 2010, 39(1): 241-263.
[33] TU R S, MARULLO R, PYNN R, et al. Cooperative DNA binding and assembly by a bZip peptide-amphiphile[J]. Soft Matter, 2010, 6(5): 1035-1044.
[34] LI L L, XU J H, QI G B, et al. Core-shell supramolecular gelatin nanoparticles for adaptive and “on-demand” antibiotic delivery[J]. ACS Nano, 2014, 8(5): 4975-4983.
[35] RECHES M, GAZIT E. Formation of closed-cage nanostructures by self-assembly of aromatic dipeptides[J]. Nano Lett, 2004, 4(4):581-585.
[36] STEPHANOPOULOS N, ORTONY J H, STUPP S I. Self-assembly for the synthesis of functional biomaterials[J]. Acta Mater, 2013, 61(3): 912-930.
[37] KE P C, SANI M A, DING F, et al. Implications of peptide assemblies in amyloid diseases[J]. Chem Soc Rev, 2017, 46(21): 6492-6531.
[38] AMIT M, CHENG G, HAMLEY I W, et al. Conductance of amyloid β based peptide filaments: structure-function relations[J]. Soft Matter, 2012, 8(33): 8690-8696.
[39] IVNITSKI D, AMIT M, SILBERBUSH O, et al. The strong influence of structure polymorphism on the conductivity of peptide fibrils[J]. Angew Chem Int Ed, 2016, 55(34): 9988-9992.
[40] AMIT M, YURAN S, GAZIT E, et al. Tailor-made functional peptide self-assembling nanostructures[J]. Adv Mater, 2018, 30(41): e1707083.
[41] MANLUNG M, YI K, YUAN G, et al. Aromatic-aromatic interactions induce the self-assembly of pentapeptidic derivatives in water to form nanofibers and supramolecular hydrogels[J]. J Am Chem Soc, 2010, 132(8):2719-2728.
[42] JAYAWARNA V, ALI M, JOWITT T A, et al. Nanostructured hydrogels for three-dimensional cell culture through self-assembly of fluorenyl methoxycarbonyl dipeptides[J]. Adv Mater, 2006, 18(5): 611-614.
[43] FICHMAN G, GUTERMAN T, ADLER-ABRAMOVICH L, et al. Synergetic functional properties of two-component single amino acid-based hydrogels[J]. CrystEngComm, 2015, 17(42): 8105-8112.
[44] ZHU K, HOU D, FEI Y, et al. Thermosensitive hydrogel interface switching from hydrophilic lubrication to infection defense[J]. ACS Appl Bio Mater, 2019, 2(8): 3582-3590.
[45] LIU L, XU K, WANG H, et al. Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent[J]. Nat Nanotechnol, 2009, 4(7): 457-463.
[46] LEI R, HOU J, CHEN Q, et al. Self-assembling myristoylated human alpha-defensin 5 as a next-generation nanobiotics potentiates therapeutic efficacy in bacterial infection[J]. ACS Nano, 2018, 12(6): 5284-5296.
[47] LI L L, MA H L, QI G B, et al. Pathological-condition-driven construction of supramolecular nanoassemblies for bacterial infection detection[J]. Adv Mater, 2016, 28(2): 254-262.
[48] QI G B, ZHANG D, LIU F H, et al. An “on-site transformation” strategy for treatment of bacterial infection[J]. Adv Mater, 2017, 29(36): 1703461.
[49] FLEMMING H C, WINGENDER J, SZEWZYK U, et al. Biofilms: an emergent form of bacterial life[J]. Nat Rev Microbiol, 2016, 14(9): 563-575.
[50] JU X, CHEN J, ZHOU M, et al. Combating Pseudomonas aeruginosa biofilms by a chitosan-PEG-peptide conjugate via changes in assembled structure[J]. ACS Appl Mater Interfaces, 2020, 12(12): 13731-13738.
[51] REIGHARD K P, HILL D B, DIXON G A, et al. Disruption and eradication of P.aeruginosa biofilms using nitric oxide-releasing chitosan oligosaccharides[J]. Biofouling, 2015, 31(9-10): 775-787.
[52] JARDELEZA C, FOREMAN A, BAKER L, et al. The effects of nitric oxide on Staphylococcus aureus biofilm growth and its implications in chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2011, 1(6): 438-444.
[53] TANG R, JIANG F, WEN J, et al. Managing bacterial biofilms with chitosan-based polymeric nitric oxides: inactivation of biofilm bacteria and synergistic effects with antibiotics[J]. J Bioact Compat Polym, 2016, 31(4): 393-410.
[54] JENAL U, REINDERS A, LORI C. Cyclic di-GMP: second messenger extraordinaire[J]. Nat Rev Microbiol, 2017, 15(5): 271-284.
[55] FEI Y, WU J, AN H W, et al. Identification of new nitric oxide-donating peptides with dual biofilm eradication and antibacterial activities for intervention of device-related infections[J]. J Med Chem, 2020, 63(17): 9127-9135.
[56] CAMPOY E, COLOMBO M I. Autophagy in intracellular bacterial infection[J]. Biochim Biophys Acta, 2009, 1793(9): 1465-1477.
[57] CAI Q, FEI Y, AN H W, et al. Macrophage-instructed intracellular Staphylococcus aureus killing by targeting photodynamic dimers[J]. ACS Appl Mater Interfaces, 2018, 10(11): 9197-9202.

Research Progress of the Peptide-Based Self-assembled Nanomaterials Against Microbial Resistance

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Hui-Hui LI, Kai-Sheng YAO, Ya-Nan ZHAO, Li-Na FAN, Yu-Lin TIAN, Wei-Wei LU. Ionic Liquid-Modulated Synthesis of Pt-Pd Bimetallic Nanomaterials and Their Catalytic Performance for Ammonia Borane Hydrolysis to Generate Hydrogen [J]. Chinese Journal of Applied Chemistry, 2023, 40(4): 597-609.
[2]	Yu-Zhu CHEN, Si-Si LIU, Meng-Meng ZHANG, Xiang-De LIN, Dong-Dong ZENG. Polyurethane Dressing Based on Antibacterial Chitosan/Carboxymethyl Cellulose Composite Drug Coating [J]. Chinese Journal of Applied Chemistry, 2023, 40(2): 252-260.
[3]	Xiao-Hu LIU, Xiao-Juan LAI, Hong-Yan CAO, Ting-Ting WANG, Zhi-Qiang DANG. Synergistic Performance of Foaming Agent/Stabilizer/SiO₂ Composite Foam Retarded Acid System [J]. Chinese Journal of Applied Chemistry, 2023, 40(1): 91-99.
[4]	Kai WANG, Hai-Kuan YANG, Hui-Lan LIU, Jia-Min LU, Chen ZHANG. Synthesis and Gelation Properties of Stigmasterol‑Based Supramolecular Gelators [J]. Chinese Journal of Applied Chemistry, 2022, 39(9): 1453-1463.
[5]	Xin HE, Cai-Yun JIANG, Tao DING, Yu-Ping WANG. Reserch Progress of Preparation of Ordered Surface Enhanced Raman Scattering Substrate [J]. Chinese Journal of Applied Chemistry, 2022, 39(8): 1167-1176.
[6]	Wei-Qiang ZHANG, Chen WANG, Yu-Rong ZHAO, Dong WANG, Ji-Qian WANG, Hai XU. Research Progress of Regulation of Driving Forces in Short Peptide Supramolecular Self‑Assembly [J]. Chinese Journal of Applied Chemistry, 2022, 39(8): 1190-1201.
[7]	Zi-Li LI, Xing-Ran XU, Jiang-Hao ZHAN, Xiao-Hua HU, Zi-Ying ZHANG, Shi-Sheng XIONG. Advanced Materials for Lithography [J]. Chinese Journal of Applied Chemistry, 2022, 39(6): 859-870.
[8]	Hui DU, Chen-Yang YAO, Hao PENG, Bo JIANG, Shun-Xiang LI, Jun-Lie YAO, Fang ZHENG, Fang YANG, Ai-Guo WU. Applications of Transition Metal⁃doped Iron⁃based Nanoparticles in Biomedicine [J]. Chinese Journal of Applied Chemistry, 2022, 39(3): 391-406.
[9]	HU Xiao-Hua, XIONG Shi-Sheng. Advanced Lithography: Directed Self-Assembly [J]. Chinese Journal of Applied Chemistry, 2021, 38(9): 1029-1078.
[10]	TIAN Xin, LAI Han-Wen, LIU Ya-Dong, JI Sheng-Xiang. Analysis of Defects in Block Copolymer Films by a Convolution Algorithm [J]. Chinese Journal of Applied Chemistry, 2021, 38(9): 1199-1208.
[11]	WANG Hou-Chen, ZHOU Li, LIU Yang, CHEN Ming-Yue, SHI Tie-Sheng. Research Progress on the Molecular Designs of Building Blocks for Supramolecular Aggregates and Self-Assemblies [J]. Chinese Journal of Applied Chemistry, 2021, 38(6): 615-621.
[12]	HUANG Xiao-Tong, CHEN Ying-Xin, ZHU Ze-Bin, ZHOU Li-Hua. Research Progress on Detection of Ascorbic Acid by Nanomaterial-Based Spectral Analysis Method [J]. Chinese Journal of Applied Chemistry, 2021, 38(6): 637-650.
[13]	LYU Zhao-Feng, CHEN Shi-Heng, WANG Nan, BAI Cui, XIAO Dan. Analysis of Amino Acid Sequence of Antimicrobial Peptides in the Fermentation Broth of Paecilomyces hepiali by RP-HPLC-MS [J]. Chinese Journal of Applied Chemistry, 2021, 38(3): 298-304.
[14]	LIU Lin-Chang, GUO Ya-Jun, ZHU Hong-Lin, MA Jing-Jing, LI Zhong-Yi, SHUI Miao, ZHENG Yue-Qing. Research Progress on Supported Ultrafine Nano-catalysts for Hydrolytic Dehydrogenation of Ammonia Borane [J]. Chinese Journal of Applied Chemistry, 2021, 38(11): 1405-1422.
[15]	CHEN Song-Hua, CHEN Xin, LIU Yong-Qi, HE Mei-Yun, FU Shan-Shan, PENG Li, YANG Ji-En. Preparation and Optical Waveguide Property of Benzothiadiazole-Containing One Dimensional Micro-nanowires [J]. Chinese Journal of Applied Chemistry, 2021, 38(11): 1479-1485.