Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (5): 546-558.DOI: 10.19894/j.issn.1000-0518.210057

• Review • Previous Articles     Next Articles

Research Progress of the Peptide-Based Self-assembled Nanomaterials Against Microbial Resistance

LIU Jiao1,3, ZOU Peng-Fei1,3, LI Ping3, ZHANG Xiao1, WANG Xin-Xin2, GAO Yuan-Yuan1*, LI Li-Li3*   

  1. 1School of Pharmacy, Weifang Medical University, Weifang 261000, China
    2School of Life Science and Technology , Weifang Medical University, Weifang 261000, China
    3CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100109, China
  • Received:2021-01-30 Accepted:2021-03-10 Published:2021-05-01 Online:2021-07-01
  • Supported by:
    National Key R&D Program Project (No.2018YFE0205400), the National Natural Science Foundation of China (Nos.51873045, 3160040663, 31600775), the Youth Innovation Promotion, CAS (No.2017053)

Abstract: Bacterial infections, especially drug-resistant bacterial infections, are one of the greatest threats to human health. Peptides play an important role in the treatment of drug-resistant bacterial infections due to their good biocompatibility and a mechanism significantly less prone to inducing resistance. Among them, the biomimetic nanostructures prepared from peptide self-assembled nanomaterials show unique advantages in resisting infections by resistant-bacteria. Nowadays, peptide self-assembled nanomaterials have been used in the treatment of drug-resistant bacterial infections. For example, they often target at cell membranes where bacterias are less likely to develop resistance. In addition, peptide self-assembled nanomaterials have a good advantage of acting on bacterial biofilms and treating intractable bacterial infections because of their unique particle size and biological characteristics. Therefore, it is of great significance to fight against drug-resistant bacterial infections with peptide self-assembled nanomaterials consisted of different components. In this review, the secondary structure of peptides and the main nanostructures formed by peptide self-assembly were summarized. What′s more, the strategies of peptide self-assembled nanomaterials against drug-resistant bacteria were demonstrated. Finally, the prospects and remaining challenges of peptide self-assembled nanomaterials as antibacterial agents in clinical applications were introduced. Therefore, we hope to provide some references for their further applications by this minireview.

Key words: Peptide, Self-assembly, Nanomaterials, Resistance to drug-resistant bacteria

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