Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (3): 391-406.DOI: 10.19894/j.issn.1000-0518.210394

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Applications of Transition Metal⁃doped Iron⁃based Nanoparticles in Biomedicine

Hui DU1,3, Chen-Yang YAO1,3, Hao PENG1,3, Bo JIANG1, Shun-Xiang LI1, Jun-Lie YAO1, Fang ZHENG1, Fang YANG1,2(), Ai-Guo WU1,2()   

  1. 1.Zhejiang Biomedical Materials Technology and Application International Science and Technology Cooperation Base,Key Laboratory of Magnetic Materials and Devices,Zhejiang Engineering Research Center for ImplantInterventional Materials,Cixi Institute of Biomedical Engineering,Ningbo Institute of Materials Technologyand Engineering,Chinese Academy of Sciences,Ningbo 315201,China
    2.Guangdong Laboratory of Advanced Energy Science and Technology,Huizhou 516000,China
    3.University of Chinese Academy of Sciences,Beijing 100049,China
  • Received:2021-08-07 Accepted:2021-11-03 Published:2022-03-01 Online:2022-03-15
  • Contact: Fang YANG,Ai-Guo WU
  • About
  • Supported by:
    the National Natural Science Foundation of China(32025021);the Ministry of Science and Technology of China(2018YFC0910601);the Department of Science and Technology of Zhejiang Province(2020C03110);the Science and Technology Bureau of Ningbo Municipality(2020Z094)


Magnetic nanomaterials (MNPs) have been extensively studied and applied in the past half century due to their unique properties including coordinated magnetic properties, non-invasive, easy manipulation, and good biocompatibility. However, the complex magnetic behavior of MNPs is influenced by a variety of factors, including particle size, composition, shape, and core-shell structure. Therefore, the main parameters of MNPs are needed to coordinate accordingly for specific applications to improve their effectiveness. Among them, doping of divalent transition metal ions is a crucial parameter affecting various magnetic properties of MNPs such as magnetic moment (μ), saturation magnetization strength (Ms), coercivity (Hc), magnetic crystal anisotropy (K) and relaxation time (τN and τB). Therefore, this review focuses on the mechanism of precisely regulating the magnetic properties of magnetic nanomaterials by doping them with transition metal ions, and introduces the potential mechanisms and some recent advances of MNPs doped with transition metal ions for bioimaging detection (magnetic resonance imaging and magnetic particle imaging), drug precision delivery and tumor therapy, and biosensing. Finally, we summarize some challenges and future trends of MNPs.

Key words: Magnetic nanomaterials, Transition metal doping, Magnetic coordination mechanism, Bioimaging, Tumor therapy, Drug delivery, Biosensing

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