Phenylboronic Acid-Based Glucose-Sensitive Polymer Nanocarriers Used as Drug Delivery Systems

doi:10.11944/j.issn.1000-0518.2017.07.170035

Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (7): 733-743.DOI: 10.11944/j.issn.1000-0518.2017.07.170035

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Phenylboronic Acid-Based Glucose-Sensitive Polymer Nanocarriers Used as Drug Delivery Systems

HUANG Qiongwei^a,ZHAO Li^b,SONG Zhiming^c,FENG Xiangru^d,DING Jianxun^d^*()

^aChina-Japan Union Hospital of Jilin University,Changchun 130033,China
^bCollege of Material Science and Engineering,Jilin Jianzhu University,Changchun 130118,China
^cFirst Hospital of Jilin University,Changchun 130021,China
^dKey Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China

Received:2017-02-15 Accepted:2017-04-20 Published:2017-07-04 Online:2017-07-04
Contact: DING Jianxun
Supported by:
Supported by the National Natural Science Foundation of China(No.51403075, No.51673190, No.51303174, No.51390484), the Scientific Development Program of Jilin Province(No.20140520050JH, No.20170520153JH)

Abstract

Abstract:

Recently, the smart glucose-sensitive self-regulated drug delivery systems have attracted extensive attention. These smart drug delivery platforms can mimic the physiological model of pancreatic insulin secretion with a timely precise drug dose to control the blood glucose level effectively, and has broad application prospects in the treatment of diabetes. Phenylboronic acid(PBA)-functionalized glucose-sensitive polymer nanocarriers have been studied widely and have great stability, long term storability, and reversible glucose-sensitivity. According to response factors, there are pH-, temperature-, and light-responsive nanocarriers for glucose-sensitive drug delivery. This review covers the development, properties, and applications of glucose sensitive nanocarriers based on PBA, and the prospects are predicted.

Key words: glucose-sensitivity, phenylboronic acid, polymer nanocarrier, drug delivery, diabetes therapy

HUANG Qiongwei,ZHAO Li,SONG Zhiming,FENG Xiangru,DING Jianxun. Phenylboronic Acid-Based Glucose-Sensitive Polymer Nanocarriers Used as Drug Delivery Systems[J]. Chinese Journal of Applied Chemistry, 2017, 34(7): 733-743.

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Phenylboronic Acid-Based Glucose-Sensitive Polymer Nanocarriers Used as Drug Delivery Systems

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