Chinese Journal of Applied Chemistry

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Isolation and Structure Elucidation of Secondary Metabolites from Mangrove Endophytic Fungus Penicillium sp. (ZZF29#)

LI Shangde1*, WEI Meiyan1, LI Zhihua1, SHE Zhigang2, LIN Yongcheng2   

  1. (1.School of Pharmacy,Guangdong Medical College,Dongguan 523808,China;
    2.School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China)
  • Received:2011-09-28 Revised:2012-03-06 Published:2012-06-10 Online:2012-06-10

Abstract: The secondary metabolites of the medicinal mangrove endophytic fungus Penicillium sp.(ZZF29#) were firstly studied. Eight compounds were isolated from the ethyl acetate extract of the fermentation using silica gel column chromatography, preparative thin-layer chromatography and recrystallization. The structures of the compounds were identified as cyclo-(Phe-Ala)(1), cyclo-(Phe-Gly)(2), cyclo-(Phe-Phe)(3), cyclo-(Phe-Tyr)(4), emodin(5), physcion(6), ergosterol(7) and peroxide ergosterol(8), by comprehensive spectroscopic characterizations as well as comparison with reported data.

Key words: mangrove endophytic fungus, secondary metabolites, isolation and elucidation, cyclodipeptides, anthraquinones, sterols

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