Chinese Journal of Applied Chemistry ›› 2016, Vol. 33 ›› Issue (7): 834-840.DOI: 10.11944/j.issn.1000-0518.2016.07.150375

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Screening of Cu(Ⅱ) Ion Induced β-Amyloid Peptide Aggregation Inhibitor and Their Molecular Structure Analysis

WANG Chengkeab,WANG Zhenxinb*()   

  1. a School of Food and Biological Engineering,Jiangsu University,Zhenjiang,Jiangsu 212013,China
    b Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
  • Received:2015-10-22 Accepted:2015-12-11 Online:2016-06-30 Published:2016-06-30
  • Contact: WANG Zhenxin
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21127010, No.21305032), China Postdoctoral Science Foundation(No.2014M551522), Jiangsu Planned Projects for Postdoctoral Research Funds(No.1402073B)

Abstract:

It is very important to develop efficient drugs for the cure of Alzheimer's disease. Here, gold nanoparticle probes were utilized to acquire the ability of 13 kinds of compounds to inhibit the Cu2+ induced β-amyloid peptide aggregation. Ten of then were screened as the effective inhibitors. The relationships between the chemical structures and their inhibitory efficiencies were also studied as well. We also used the screened molecules to regulate the morphology changes of Cu2+-β-amyloid aggregates and to decrease the production of H2O2 formed by the interaction of Cu2+ and β-amyloid peptide. This research is significant to the study of Alzheimer's disease.

Key words: Alzheimer's disease, gold nanoparticles, inhibitor