Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (11): 1257-1265.DOI: 10.11944/j.issn.1000-0518.2019.11.190139

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Whitening and Antioxidant Activities of Phenolic Derivatives

JIN Yutinga,ZHI Defuc,GUO Yongtaia,SUI Yuea,SUN Leia,ZWANG Qiana,HAO Longxuanab*(),ZHAO Chunhuib()   

  1. a Liaoning Normal University,School of Chemistry and Chemical Engineering,Dalian,Liaoning 116029,China
    b Liaoning Normal University Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery,Dalian,Liaoning 116029,China
    c Dalian Nationalities University College of Life Science,Dalian,Liaoning 116600,China
  • Received:2019-05-14 Accepted:2019-08-19 Published:2019-11-01 Online:2019-11-05
  • Contact: HAO Longxuan
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21101067)

Abstract:

A series of phenolic derivatives was synthesized and characterized by Fourier transform infrared spectrometer(FTIR), nuclear magnetic resonance spectroscopy(NMR) and electrospray ionisation mass spectrometry(ESI-MS). Their whitening activity was also tested. The results showed that the tyrosinase inhibitory activities HB-1(0.229±0.026), HB-3a(0.829±0.135), HB-3b(0.446±0.047), HMB-3a(1.747±0.215), HMB-3b(1.307±0.058) and HPE-4b(2.501±0.261) were significantly better than those of the positive control, α-arbutin (3.60±0.029). The antioxidant activities of these compounds were tested to whitening potentials. The results showed that the antioxidant activities of HB-3b and HMB-3a were comparable to the positive control substance quercetin and lycopene. Therefore, such compounds can be developed and utilized as whitening agents and antioxidants.

Key words: penolic compounds, tyrosinase inhibitor, anti-oxidant