Screening of Cu(Ⅱ) Ion Induced β-Amyloid Peptide Aggregation Inhibitor and Their Molecular Structure Analysis

doi:10.11944/j.issn.1000-0518.2016.07.150375

Chinese Journal of Applied Chemistry ›› 2016, Vol. 33 ›› Issue (7): 834-840.DOI: 10.11944/j.issn.1000-0518.2016.07.150375

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Screening of Cu(Ⅱ) Ion Induced β-Amyloid Peptide Aggregation Inhibitor and Their Molecular Structure Analysis

WANG Chengke^a^b,WANG Zhenxin^b^*()

^a School of Food and Biological Engineering,Jiangsu University,Zhenjiang,Jiangsu 212013,China
^b Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China

Received:2015-10-22 Accepted:2015-12-11 Published:2016-06-30 Online:2016-06-30
Contact: WANG Zhenxin
Supported by:
Supported by the National Natural Science Foundation of China(No.21127010, No.21305032), China Postdoctoral Science Foundation(No.2014M551522), Jiangsu Planned Projects for Postdoctoral Research Funds(No.1402073B)

Abstract

Abstract:

It is very important to develop efficient drugs for the cure of Alzheimer's disease. Here, gold nanoparticle probes were utilized to acquire the ability of 13 kinds of compounds to inhibit the Cu²⁺ induced β-amyloid peptide aggregation. Ten of then were screened as the effective inhibitors. The relationships between the chemical structures and their inhibitory efficiencies were also studied as well. We also used the screened molecules to regulate the morphology changes of Cu²⁺-β-amyloid aggregates and to decrease the production of H₂O₂ formed by the interaction of Cu²⁺ and β-amyloid peptide. This research is significant to the study of Alzheimer's disease.

Key words: Alzheimer's disease, gold nanoparticles, inhibitor

WANG Chengke, WANG Zhenxin. Screening of Cu(Ⅱ) Ion Induced β-Amyloid Peptide Aggregation Inhibitor and Their Molecular Structure Analysis[J]. Chinese Journal of Applied Chemistry, 2016, 33(7): 834-840.

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Screening of Cu(Ⅱ) Ion Induced β-Amyloid Peptide Aggregation Inhibitor and Their Molecular Structure Analysis

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