Recent Advances in Small-Molecule Organic Fluorescent Probes for Hydrazine

doi:10.19894/j.issn.1000-0518.240328

Chinese Journal of Applied Chemistry ›› 2025, Vol. 42 ›› Issue (4): 453-465.DOI: 10.19894/j.issn.1000-0518.240328

• Review •

Recent Advances in Small-Molecule Organic Fluorescent Probes for Hydrazine

Ling LI¹, Li-Ting TANG², Jun-Jie YANG², Li-Qiang YAN¹^,²(), Jian-Ping LI¹^,²()

^1.College of Environmental Science and Engineering，Guilin University of Technology，Guilin 541006，China
^2.College of Chemistry and Bioengineering，Guilin University of Technology，Guilin 541006，China

Received:2024-10-19 Accepted:2025-02-24 Published:2025-04-01 Online:2025-05-14
Contact: Li-Qiang YAN,Jian-Ping LI
Supported by:
the National Natural Science Foundation of China(22364010);the Natural Science Foundation of Guangxi Province(2024GXNSFAA010223)

Abstract

Abstract:

Hydrazine （N₂H₄） is a crucial chemical precursor with significant applications in chemical production. However， hydrazine is highly toxic and exhibits excellent water solubility. Its widespread use and potential leakage pose substantial risks to human health and environmental safety. Consequently， the effective monitoring of hydrazine in biological and environmental samples is of paramount importance. Organic small-molecule fluorescent probes， characterized by their high sensitivity， excellent selectivity， rapid response time， offer a reliable， convenient， and visual method for detecting target substances in complex samples. Fluorescence probe technique shows great promise in facilitating the detection of hydrazine. In recent years， notable advancements have been made in organic small-molecule fluorescent probes for hydrazine detection. This paper reviews the latest research findings on hydrazine probes since 2023， based on their chemical reaction mechanisms. By comparing and analyzing their design strategies， detection performance， and application scope， this review highlights the outstanding advantages of hydrazine probes， identifies existing challenges， and predicts future development trends.

Key words: Fluorescent probe, Hydrazine, Analysis and detection

CLC Number:

O657.3

Ling LI, Li-Ting TANG, Jun-Jie YANG, Li-Qiang YAN, Jian-Ping LI. Recent Advances in Small-Molecule Organic Fluorescent Probes for Hydrazine[J]. Chinese Journal of Applied Chemistry, 2025, 42(4): 453-465.

Figures/Tables 7

Fig.1 The main mechanisms of fluorescent probes for detecting hydrazine

Fig.2 Structures and response mechanisms of probes 1-10［7-16］

Fig.3 Structures and response mechanisms of probes 11-18［17-24］

Fig.4 Structures and response mechanisms of probes 19-26［25-32］

Fig.5 Structures and response mechanisms of probes 27-33［33-37，30，38］

Fig.6 Structures and response mechanisms of probes 34-39［39-44］

Fig.7 Structures and response mechanisms of probes 40-46［45-51］

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Recent Advances in Small-Molecule Organic Fluorescent Probes for Hydrazine

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