Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (3): 407-424.DOI: 10.19894/j.issn.1000-0518.210583

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Progress of Mitochondria⁃Targeted Near⁃Infrared HClO/ClO- Fluorescent Probes

Rui HUANG1, Chang-Qing YE2, Ya-Jun LI2, Mong-Feng CHIOU2, Da-Liang LI1(), Hong-Li BAO2()   

  1. 1.College of Life Sciences,Fujian Normal University,Fuzhou 350117,China
    2.Key Laboratory of Coal to Ethylene Glycol and Its Related Technology,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,China
  • Received:2021-12-29 Accepted:2022-01-05 Published:2022-03-01 Online:2022-03-15
  • Contact: Da-Liang LI,Hong-Li BAO
  • About author:hlbao@fjirsm.ac.cndaliangli@fjnu.edu.cn
  • Supported by:
    the Innovative Research Teams Program II of Fujian Normal University in China(IRTL1703);the Natural Science Foundation of Fujian Province in China(2021J01205)

Abstract:

As an important reactive oxygen species (ROS), HClO/ClO- can retrospect to mitochondria and participates in various physiological and pathological processes. Therefore, it is particularly important to develop an effective method to detect HClO/ClO- in the biology and physiology. Fluorescence analysis has attracted much attention because of its high sensitivity, fast response time, low cost, and easy operation. More importantly, the use of fluorescent probes can visualize the detection process in vitro and in vivo. In recent years, to study the role of hypochlorous acid in cells, many mitochondria-targeted fluorescent HClO/ClO- probes have been designed and synthesized. Among them, some probes in the short-wavelength region suffer from some shortages, such as high autofluorescence and poor tissue penetration. Therefore, it is of great significance to develop HClO/ClO- probes with far-infrared to near-infrared emission. This article focuses on the latest developments of mitochondrial-targeted near-infrared fluorescent probes used to detect HClO/ClO- and summarizes their possible reaction mechanisms which are mainly divided into the oxidation of unsaturated double bonds, the oxidation of thioethers, the oxidation of amino groups or hydrazides and oxidation multi-sites. It is expected to be beneficial to develop the novel specific fluorescent probes in the monitoring of physiological and pathological HClO/ClO-.

Key words: Mitochondria, Fluorescent probe, Near infrared, Hypochlorous acid

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