Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (7): 1098-1107.DOI: 10.19894/j.issn.1000-0518.210282

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Detection of Dopamine by Enzyme‑Free Sensor Constructed by Nickel‑Cobalt Bimetallic‑porphyrin Organic Framework Composites

Shan SHAO, Jian ZHANG, Kai-Qiang DENG, Jie YANG, Shao-Ming YANG()   

  1. School of Materials Science and Engineering,East China Jiaotong University,Nanchang 330013,China
  • Received:2021-06-10 Accepted:2021-10-19 Published:2022-07-01 Online:2022-07-11
  • Contact: Shao-Ming YANG
  • About author:yangsm79@
  • Supported by:
    the National Natural Science Foundation of China(21465012)


Metal organic framework materials (MOFs) as catalytic materials were synthesized using Ni and Co as metal nodes and 5,10,15,20-tetra (4-carboxylphenyl) porphyrin (TCPP) as the metal ligand. Reduced graphene oxide (rGO) and acetylene black (ACET) were used as the signal amplification materials to fabricate an enzyme-free electrochemical sensor with high sensitivity, stability and selectivity for detecting dopamine (DA). rGO-NiCoTCPP was synthesized by one-step hydrothermal method, then modified by drop coating on the glassy carbon electrode, i.e., the GCE/rGO-NiCoTCPP electrode, and finally ACET was dropped on this electrode to obtain the rGO-NiCoTCP/ACET electrode. This electrode was characterized by infrared spectroscopy, scanning electron microscopy, electrochemical impedance, and different modified electrodes were placed in phosphoric acid buffer for electrochemical characterization by cyclic voltammetry. rGO-NiCoTCPP/ACET sensors have a wide linear range (0.4~160 μmol/L) and a high current response (limit of detection is 0.198 μmol/L) for DA, expected to be applied to the detection of DA in real samples.

Key words: Bimetallic organic framework materials, Electrochemical sensor, Dopamine, Oreduce graphene oxide, Acetylene black

CLC Number: