Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (7): 866-873.DOI: 10.19894/j.issn.1000-0518.210008

• Full Papers • Previous Articles     Next Articles

Sensing Interface Based on Nanoislandlike Sliver Film@Gold Nanotip for Surface Enhanced Raman Scattering Analysis of Dopamine

ZHANG Meng1‡, CHEN Dong-Zhen2‡*, REN Yan-Wei2, NING Pan3   

  1. 1The First Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710061, China
    2Key Laboratory of Functional Textile Sensing Fiber and Irregular Shape Weaving Technology, School of Materials Science & Engineering, Xi′an Polytechnic University, Xi′an 710048, China
    3Key Laboratory of Biomedical Information Engineering of Education Ministry, Xi′an Jiaotong University, Xi′an 710049, China
  • Received:2021-01-06 Accepted:2021-04-10 Published:2021-07-01 Online:2021-09-01
  • About author:National Natural Science Foundation of China (No.81801122) and the Natural Science Basic Research Program of Shaanxi (No.2020JQ-529)

Abstract: Dopamine deficiency is the main cause of the clinical symptoms of Parkinson′s disease. Highly sensitive detection of dopamine is crucial for understanding the brain function and studying the information processing in neural networks. A silver film with micro-nano island structures was fabricated employing the magnetron sputtering technology, and gold nanostructures with multi-nanometer tips were prepared by using alkaline hydrogen peroxide as clean reducing agent. Then, dopamine was sandwiched between the silver film and the gold nanostructures. Through the interface “hot spot” between the silver film and the gold nanotip, Raman signal of dopamine is effectively enhanced, and the detection of dopamine in urine samples is also realized. The constructed interface of silver film@gold nanotip has excellent performance of surface-enhanced Raman spectroscopy (SERS), which has the advantages of sensitivity and anti-interference ability during the analysis of biomarker molecules and hazardous chemical molecules.

Key words: Noble metal nanostructure, Detection of disease marker, Dopamine, Surface-enhanced Raman spectroscopy sensing, Sensitivity

CLC Number: