Preparation and Properties of Polydopamine and Alginate Porous Complex Scaffolds

doi:10.11944/j.issn.1000-0518.2018.06.170173

Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (6): 665-673.DOI: 10.11944/j.issn.1000-0518.2018.06.170173

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Preparation and Properties of Polydopamine and Alginate Porous Complex Scaffolds

ZHANG Zhuying,CHEN Jing,YU Jialei,ZHAO Qian,CAO Chuanhao,SHEN Jiali,SHI Dongjian()

Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,School of Chemical and Material Engineering,Jiangnan University,Wuxi,Jiangsu 214122,China

Received:2017-05-25 Accepted:2017-09-07 Published:2018-06-01 Online:2018-05-28
Contact: SHI Dongjian
Supported by:
Supported by the Jiangsu Province College Students Innovation and Entrepreneurship Training Program(No.201610295019Y)

Abstract

Abstract:

Alginate(Alg) is widely used in the field of tissue engineering because of its safe, non-toxic and biodegradable properties. Inspired by mussel adhesive protein, dopamine(DA) has excellent adhesion property and can self-oxidize to polydopamine(PDA) in weak basic buffer solution. Alg/PDA porous scaffolds were prepared by freeze-dry of Alg and PDA mixture. The results show that Alg/PDA porous scaffolds have relatively homogeneous internal structure. By changing the mass concentration of Alg, the pore size of the Alg/PDA complex scaffolds can be limited to 60~120 μm, and the porosity of the scaffolds can be controlled in the range of 80%~88% which is appropriate for the growth of bond cells. The biocompatibility results indicate that the scaffolds show low cytotoxicity.

Key words: dopamine, alginate, porous scaffold

ZHANG Zhuying,CHEN Jing,YU Jialei,ZHAO Qian,CAO Chuanhao,SHEN Jiali,SHI Dongjian. Preparation and Properties of Polydopamine and Alginate Porous Complex Scaffolds[J]. Chinese Journal of Applied Chemistry, 2018, 35(6): 665-673.

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Preparation and Properties of Polydopamine and Alginate Porous Complex Scaffolds

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