Efficient Preparation of Polydopamine Nanoparticles by Precipitation

doi:10.11944/j.issn.1000-0518.2019.02.180150

Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (2): 155-160.DOI: 10.11944/j.issn.1000-0518.2019.02.180150

• Full Paper • Previous Articles Next Articles

Efficient Preparation of Polydopamine Nanoparticles by Precipitation

WANG He,LUO Jing,LI Xiaojie(),SHI　Dongjian,CHEN　Mingqing

Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,School of Chemical and Material Engineering,Jiangnan University,Wuxi,Jiangsu 214122,China

Received:2018-05-03 Published:2019-02-01 Online:2019-01-31
Contact: LI Xiaojie
Supported by:
Supported by the Fundamental Research Funds for the Central Universities(No.JUSRP115A07), the Jiangsu Planned Projects for Postdoctoral Research Funds(No.1601237C), the Open Research Fund of Key Laboratory of Synthetic and Biological Colloids(Jiangnan University), Ministry of Education(No.JDSJ2016-06)

Abstract

Abstract:

In order to obtain dispersive and stable polydopamine nanoparticles, an aqueous dispersion of polydopamine nanoparticles was efficiently prepared using the “precipitation-redispersion” method. First, polydopamine nanoparticles dispersed in water/ethanol were prepared by a solution oxidation method, and then acetone was added to the dispersion to flocculate the polydopamine nanoparticles. The precipitate was collected, rinsed with acetone and dried, and then redispersed in water to obtain a purified aqueous dispersion of polydopamine nanoparticles. The polydopamine nanoparticles obtained by the acetone precipitation method are regular in shape with good dispersibility. The particle size distribution is about 250 nm, and has good storage stability and photothermal properties in water. Compared with conventional ultracentrifugation purification method, the yield increases by 57.4%. This method is essential for further applications in drug delivery and photothermal therapy.

Key words: polydopamine nanoparticles, precipitation method, purification

WANG He, LUO Jing, LI Xiaojie, SHI　Dongjian, CHEN　Mingqing. Efficient Preparation of Polydopamine Nanoparticles by Precipitation[J]. Chinese Journal of Applied Chemistry, 2019, 36(2): 155-160.

References

[1]	Sedó J,Saiz-Poseu J,Busqué F,et al. Catechol-based Biomimetic Functional Materials[J]. Adv Mater,2013,25(5):653-701.
[2]	Burzio L A,Waite J H.Cross-linking in Adhesive Quinoproteins:Studies with Model Decapeptides[J]. Biochemistry,2000,39(36):11147-11153.
[3]	van der Leeden M C. Are Conformational Changes, Induced by Osmotic Pressure Variations, the Underlying Mechanism of Controlling the Adhesive Activity of Mussel Adhesive Proteins?[J]. Langmuir,2005,21(24):11373-11379.
[4]	Yang J,Cohen Stuart M A,Kamperman M. Jack of All Trades:Versatile Catechol Crosslinking Mechanisms[J]. Chem Soc Rev,2014,43(24):8271-8298.
[5]	Lu Q,Danner E,Waite J H,et al. Adhesion of Mussel Foot Proteins to Different Substrate Surfaces[J]. J R Soc Interface,2013,10(79):20120759-20120759.
[6]	Zhang C,Gong L,Xiang L,et al. Deposition and Adhesion of Polydopamine on Surfaces of Varying Wettability[J]. ACS Appl Mater Interfaces,2017,9(36):30943-30950.
[7]	Zhao P C,Wei K C,Feng Q,et al. Mussel-Mimetic Hydrogels with Defined Cross-linkers Achieved via Controlled Catechol Dimerization Exhibiting Tough Adhesion for Wet Biological Tissues[J]. Chem Commun,2017,53(88):12000-12003.
[8]	Hofman A H,Van I H,Yang J,et al. Bioinspired Underwater Adhesives by Using the Supramolecular Toolbox[J]. Adv Mater,2018,30(19):1704640-1704678.
[9]	Liebscher J,Mrówczyński R,Scheidt H A,et al. Structure of Polydopamine:A Never-Ending Story?[J]. Langmuir,2013,29(33):10539-10548.
[10]	Batul R,Tamanna T,Khaliq A,et al. Recent Progress in the Biomedical Applications of Polydopamine Nanostructures[J]. Biomater Sci,2017,5(7): 1204-1229.
[11]	Liu Y,Ai K,Lu L.Polydopamine and Its Derivative Materials:Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields[J]. Chem Rev,2014,114(9):5057-5115.
[12]	Ryu J H,Messersmith P B,Lee H.Polydopamine Surface Chemistry:A Decade of Discovery[J]. ACS Appl Mater Interfaces,2018,10(9): 7523-7540.
[13]	Schlaich C,Wei Q,Haag R.Mussel-Inspired Polyglycerol Coatings with Controlled Wettability:From Superhydrophilic Towards Superhydrophobic Surface Coatings[J]. Langmuir,2017,33(38):9508-9520.
[14]	Orishchin N,Crane C C,Brownell M,et al. Rapid Deposition of Uniform Polydopamine Coatings on Nanoparticle Surfaces with Controllable Thickness[J]. Langmuir,2017,33(24):6046-6053.
[15]	Kan B,Zhang Q,Li M,et al. Solution-Processed Organic Solar Cells Based on Dialkylthiol-substituted Benzodithiophene Unit with Efficiency near 10%[J]. J Am Chem Soc,2014,136(44):15529-15532.
[16]	Lynge M E,Philipp S,Brigitte S D.Recent Developments in Poly(dopamine)-Based Coatings for Biomedical Applications[J]. Nanomedicine,2015,10(17):2725-2742.
[17]	Wang X,Wang C,Wang X,et al. A Polydopamine Nanoparticle Knotted Poly(ethylene glycol) Hydrogel for On-Demand Drug Delivery and Chemo-photothermal Therapy[J]. Chem Mater,2017,29(3):1370-1376.
[18]	Mrówczyński R.Polydopamine-based Multifunctional(Nano)materials for Cancer Therapy[J]. ACS Appl Mater Interfaces,2017,10(9):7541-7561.
[19]	Lin X,Ma W,Wu H,et al. Superhydrophobic Magnetic Poly(DOPAm-co-PFOEA)/Fe3O4/Cellulose Microspheres for Stable Liquid Marbles[J]. Chem Commun,2016,52(9):1895-1898.
[20]	Zhang H,Zhao T,Newland B,et al. Catechol Functionalized Hyperbranched Polymers as Biomedical Materials[J]. Prog Polym Sci,2018,78(2):47-55.
[21]	Liu Y,Ai K,Liu J,et al. Dopamine-Melanin Colloidal Nanospheres:An Efficient Near-infrared Photothermal Therapeutic Agent for in Vivo Cancer Therapy[J]. Adv Mater,2013,25(9):1353-1359.
[22]	Liu S,Pan J,Liu J,et al. Dynamically PEGylated and Borate-Coordination-Polymer-Coated Polydopamine Nanoparticles for Synergetic Tumor-Targeted, Chemo-photothermal Combination Therapy[J]. Small,2018,14(13):1703968-1703980.

Efficient Preparation of Polydopamine Nanoparticles by Precipitation

RichHTML

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LI Ye-Hui, LI Xiao-Ning, HUI Wei, WANG Xiang, WANG Hai-Jun. Separation and Purification of Baicalin Using Deep Eutectic Solvent and Surfactant [J]. Chinese Journal of Applied Chemistry, 2021, 38(12): 1647-1654.
[2]	SUN Rongrong, WANG Liqiu. Low Temperature Synthesis and Characterization of Rod-Shaped LiZnPO₄ [J]. Chinese Journal of Applied Chemistry, 2019, 36(8): 924-931.
[3]	LIU Zhirong. Evaluation on Efficiencies of 11 Purification Methods Toward 50 Pesticide Residues in Angelica sinensis by Ultra-high Performance Liquid Chromatography/Tandem Mass Spectrometry [J]. Chinese Journal of Applied Chemistry, 2019, 36(8): 968-976.
[4]	SHANG Jiguang, SUN Guoxin. Extraction of Fe(Ⅲ) from Aluminum Chloride [J]. Chinese Journal of Applied Chemistry, 2018, 35(1): 75-81.
[5]	ZHANG Tianyong, YANG Yuqiu, LI Bin, WANG Zhichao, ZHANG Guoling, CHEN Song, AN Jing. Catalytic Synthesis and Purification of Bisphenol S by the Products of Converted Disodium Naphthalenedisulfonate [J]. Chinese Journal of Applied Chemistry, 2017, 34(5): 550-556.
[6]	ZHANG Tianyong, YANG Yuqiu, LI Bin, WANG Zhichao, ZHANG Guoling, CHEN Song, AN Jing. Catalytic Synthesis and Purification of Bisphenol S by the Products of Converted Disodium Naphthalenedisulfonate [J]. Chinese Journal of Applied Chemistry, 2017, 34(5): 0-0.
[7]	SHENG Bi, CHEN Zhi, LI Hongzhou, CHEN Bo*. Partition Characteristics of Geniposide in Inducing Phase Separation of Acetonitrile Aqueous Solution System [J]. Chinese Journal of Applied Chemistry, 2014, 31(02): 231-236.
[8]	CUI Yuhua1,2, YANG Jinhong1, CUI Yu1*, SUN Guoxin1, SU Benyu2. Synthesis and Characterization of High Purity Polyamidoamine Dendrimers [J]. Chinese Journal of Applied Chemistry, 2012, 29(05): 498-503.
[9]	HOU Xiaoyu, LIU Kaiqang, FANG Yu*. Progress in the Studies of Low-Molecular Mass Gelators with Phase-Selective Gelation Properties [J]. Chinese Journal of Applied Chemistry, 2011, 28(11): 1221-1228.
[10]	LIAO Min-Fu1, LIN Cui-Wu1*, HUANG Li1, XU Zi-Jing1, QIN Sa-Sa1, LI Ai-Yuan2. Isolation, Purification and Hemostatic Activity of Water-soluble Polysaccharide from Blumea riparia (BI．)DC． [J]. Chinese Journal of Applied Chemistry, 2011, 28(01): 83-87.
[11]	CAI Dong-Qing1, WU Zheng-Yan1*, WU Lin1, WU Yue-Jin1, CHU Paul K2, YU Zeng-Liang1. Removal of Impurities in Carbon Nanotubes by Low Energy Ion Beam Irradiation [J]. Chinese Journal of Applied Chemistry, 2010, 27(08): 987-989.
[12]	Han Hanmin, Li Hualong. Preparation of High Purity Tellurium [J]. Chinese Journal of Applied Chemistry, 1998, 0(5): 104-105.
[13]	Yan Yan, Zheng Goudong, Fang Chiguang, Gou Ying, Li Shaomin, Duan Weiliang. Purification of γ-Linolenic Acid from Seed Oil of Borage [J]. Chinese Journal of Applied Chemistry, 1996, 0(6): 64-66.
[14]	Chen Jing, Jiao Rongzhou, Zhu Yongjun. Purification and Properties of Cyanex 301 [J]. Chinese Journal of Applied Chemistry, 1996, 0(2): 45-48.
[15]	Ge Yizhang, Jin Hong. Extraction of Tea-Polyphenols by Precipitation Method [J]. Chinese Journal of Applied Chemistry, 1995, 0(2): 107-109.