Chinese Journal of Applied Chemistry

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Synthesis and Characterization of High Purity Polyamidoamine Dendrimers

CUI Yuhua1,2, YANG Jinhong1, CUI Yu1*, SUN Guoxin1, SU Benyu2   

  1. (1.College of Chemistry and Chemical Engineering,University of Jinan,Jinan 250022;
    2.Shandong Institute of Supervision & Inspection on Product Quality,Jinan)
  • Received:2011-06-23 Revised:2011-08-13 Published:2012-05-10 Online:2012-05-10

Abstract: 0.5G~5.0G dendrimers with ethylene diamine as core were synthesized from alternating copolymeraziation of methacrylate by Michael addition reaction. The structures of all products were characterized by FTIR, 1H NMR, HPLC, and elemental analysis. The influences of the reaction temperature, reaction time and ratio of reactants were investigated. The reaction temperature is 25 ℃ for the half-generations and 35 ℃ for the full-generations. The optimum reaction time is 18 h for 0.5G, 24 h for 1.0G and 1.5G, 36 h for 2.0G and 2.5G, 48 h for 3.0G and 3.5G, 3 d for 4.0 and 4.5G, and 4 d for 5.0G. The main difficulty in the synthesis is the separation and purification of the products. The results showed that the purity of polyamidoamine dendrimers was improved by solvent extraction using ether as extractant and ethanol as exchanged solvent.

Key words: dendrimers, polyamidoamine, synthesis, characterization, purification

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