Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (2): 155-160.DOI: 10.11944/j.issn.1000-0518.2019.02.180150

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Efficient Preparation of Polydopamine Nanoparticles by Precipitation

WANG He,LUO Jing,LI Xiaojie(),SHI Dongjian,CHEN Mingqing   

  1. Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,School of Chemical and Material Engineering,Jiangnan University,Wuxi,Jiangsu 214122,China
  • Received:2018-05-03 Published:2019-02-01 Online:2019-01-31
  • Contact: LI Xiaojie
  • Supported by:
    Supported by the Fundamental Research Funds for the Central Universities(No.JUSRP115A07), the Jiangsu Planned Projects for Postdoctoral Research Funds(No.1601237C), the Open Research Fund of Key Laboratory of Synthetic and Biological Colloids(Jiangnan University), Ministry of Education(No.JDSJ2016-06)

Abstract:

In order to obtain dispersive and stable polydopamine nanoparticles, an aqueous dispersion of polydopamine nanoparticles was efficiently prepared using the “precipitation-redispersion” method. First, polydopamine nanoparticles dispersed in water/ethanol were prepared by a solution oxidation method, and then acetone was added to the dispersion to flocculate the polydopamine nanoparticles. The precipitate was collected, rinsed with acetone and dried, and then redispersed in water to obtain a purified aqueous dispersion of polydopamine nanoparticles. The polydopamine nanoparticles obtained by the acetone precipitation method are regular in shape with good dispersibility. The particle size distribution is about 250 nm, and has good storage stability and photothermal properties in water. Compared with conventional ultracentrifugation purification method, the yield increases by 57.4%. This method is essential for further applications in drug delivery and photothermal therapy.

Key words: polydopamine nanoparticles, precipitation method, purification