Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (2): 161-169.DOI: 10.11944/j.issn.1000-0518.2019.02.180204

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Linear Maltodextrin Polymer Functionalized Fe3O4 Magnetic Nanoparticles as Drug Carriers

GONG Taoab,HUANG Yub,GUO Guoyinga,SU Dana,LIANG Wentingb*(),DONG Chuanb*()   

  1. aDepartment of Biochemistry and Molecular Biology,Shanxi Medical University,Taiyuan 030001,China
    bSchool of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China
  • Received:2018-06-04 Published:2019-02-01 Online:2019-01-31
  • Contact: LIANG Wenting,DONG Chuan
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21402110, No.21575084),

Abstract:

Linear maltodextrin polymer modified magnetic nanoparticles(LM-SP-MNPs) were prepared by chemical co-precipitation. The structure and morphology of LM-SP-MNPs were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy and thermogravimetric analysis. The loading and release behaviors of LM-SP-MNPs as drug carrier were evaluated by fluorescence spectroscopy using doxorubicin(DOX) as a model drug. The pH effects on LM-SP-MNPs for drug releasing were investigated. Under the optimal pH conditions, the maximum loading of DOX into LM-SP-MNPs is 357.1 mg/g, and the loading behavior follows Freundlich adsorption balance equations with multilayer adsorption. Furthermore, the release ability of DOX@LM-SP-MNPs is more efficient under acid solution than that under natural solution at 37 ℃ in vitro. Accumulated release efficiency of DOX in 7 h is 26.9% at pH=5.3. In addition, the MTT assays show that LM-SP-MNPs have an excellent biocompatibility, and the DOX@LM-SP-MNPs decrease the relative cellular viability of HepG2 cells evidently.

Key words: Linear maltodextrin polymer, Fe3O4 magnetic nanoparticle, doxorubicin, drug carrier