Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (12): 1485-1491.DOI: 10.11944/j.issn.1000-0518.2018.12.180064

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Upconversion Nanoparticles Decorated with Hybridization Chain Reaction DNA for Near-infrared Light Controlled Release Doxorubicin

YU Changab,SHAO Shuaiac,LI Hejied,LIU Guofengae,DING Binbinaf,MA Ping'ana*(),LIN Juna*()   

  1. aState Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
    bUniversity of Chinese Academy of Sciences,Beijing 100049,China
    cSchool of Chemistry and Environmental Engineering, Changchun University of Science and Technology,Changchun 130022,China
    dDepartment of Otorhinolaryngology Head and Neck Surgery, Second Hospital of Jilin University,Changchun 130041,China
    eCollege of Physics, Jilin University,Changchun 130012,China
    fUniversity of Science and Technology of China,Hefei 230026,China
  • Received:2018-03-09 Accepted:2018-05-02 Published:2018-12-05 Online:2018-12-10
  • Contact: MA Ping'an,LIN Jun
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.NSFC51672268, No.51472233, No.51332008, No.51720105015, No.51628201, No.21521092), the Key Research Program of Frontier Sciences, CAS(No.YZDY-SSW-JSC018), Projects for Science and Technology Development Plan of Jilin Province(No.20170101188JC, No.20170414003GH)


Nanotechnology has allowed various coatings and modifications to nanostructures for applications of biomedicine. The constructions of simple, economical, controllable and biocompatible drug delivery systems(DDS) are still in demand. Here, we report a NaYF4:Yb/Tm nanoparticle-based DDS that anticancer drug doxorubicin(Dox) could be quantitatively carried by double stranded DNA thereon that self-assembled through a hybridization chain reaction(HCR). The HCR DNA was absorbed on the surface of upconversion nanoparticles(UCNPs) through linkage to photocleavable 1-(4,5-dimethoxy-2-nitrophenyl) diazoethane(DMNPE) molecules, which can be cleaved by near ultraviolet light emitted by UCNPs under 980 nm laser light excitation. The controllable release of model drug Dox by near-infrared(NIR) should facilitate selective cytotoxicity to target region and reduced side effects and could prove promising in biomedical applications.

Key words: upconversion nanoparticles, DNA hybridization chain reaction, controllable release, doxorubicin hydrochloride