Linear Maltodextrin Polymer Functionalized Fe3O4 Magnetic Nanoparticles as Drug Carriers

doi:10.11944/j.issn.1000-0518.2019.02.180204

Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (2): 161-169.DOI: 10.11944/j.issn.1000-0518.2019.02.180204

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Linear Maltodextrin Polymer Functionalized Fe₃O₄ Magnetic Nanoparticles as Drug Carriers

GONG Tao^a^b,HUANG Yu^b,GUO Guoying^a,SU Dan^a,LIANG Wenting^b^*(),DONG Chuan^b^*()

^aDepartment of Biochemistry and Molecular Biology,Shanxi Medical University,Taiyuan 030001,China
^bSchool of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China

Received:2018-06-04 Published:2019-02-01 Online:2019-01-31
Contact: LIANG Wenting,DONG Chuan
Supported by:
Supported by the National Natural Science Foundation of China(No.21402110, No.21575084),

Abstract

Abstract:

Linear maltodextrin polymer modified magnetic nanoparticles(LM-SP-MNPs) were prepared by chemical co-precipitation. The structure and morphology of LM-SP-MNPs were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy and thermogravimetric analysis. The loading and release behaviors of LM-SP-MNPs as drug carrier were evaluated by fluorescence spectroscopy using doxorubicin(DOX) as a model drug. The pH effects on LM-SP-MNPs for drug releasing were investigated. Under the optimal pH conditions, the maximum loading of DOX into LM-SP-MNPs is 357.1 mg/g, and the loading behavior follows Freundlich adsorption balance equations with multilayer adsorption. Furthermore, the release ability of DOX@LM-SP-MNPs is more efficient under acid solution than that under natural solution at 37 ℃ in vitro. Accumulated release efficiency of DOX in 7 h is 26.9% at pH=5.3. In addition, the MTT assays show that LM-SP-MNPs have an excellent biocompatibility, and the DOX@LM-SP-MNPs decrease the relative cellular viability of HepG2 cells evidently.

Key words: Linear maltodextrin polymer, Fe₃O₄ magnetic nanoparticle, doxorubicin, drug carrier

GONG Tao, HUANG Yu, GUO Guoying, SU Dan, LIANG Wenting, DONG Chuan. Linear Maltodextrin Polymer Functionalized Fe₃O₄ Magnetic Nanoparticles as Drug Carriers[J]. Chinese Journal of Applied Chemistry, 2019, 36(2): 161-169.

References

[1]	Chabner B A,Roberts T G.Timeline:Chemotherapy and the War on Cancer[J]. Nat Rev Cancer,2005,5(1):65-72.
[2]	Yague E,Raguz S.Drug Resistance in Cancer[J]. Br J Cancer,2005,93:973-976.
[3]	SUN Linlin,ZHOU Yehong,WANG Fei,et al. Adsorption Properties of Carboxymethyl-β-cyclodextrin Functionalized Ferroferric Oxide Magnetic Nanocomposites on Rhodamine B[J]. Chinese J Appl Chem,2015,32(1):110-117(in Chinese). 孙琳琳,周叶红,王斐,等. 羧甲基-β-环糊精功能化的四氧化三铁磁性纳米复合物对罗丹明B的吸附性能[J]. 应用化学,2015,32(1):110-117.
[4]	Jin C Z,Wang Y J,Tang H L,et al. Synthesis, Characterization and Catalytic Applications of Core-Shell Magnetic Carbonaceous Nanocomposites[J]. J Phys Chem,2014,118(23):25110-25117.
[5]	Ding Y,Yin H,Sun K N,et al. Chitosan-based Magnetic/fluorescent Nanocomposites for Cell Labelling and Controlled Drug Release[J]. New J Chem,2017,41(4):1736-1743.
[6]	Chowdhuri A R,Singh T,Ghosh S K,et al. Carbon Dots Embedded Magnetic Nanoparticles@Chitosan@Metal Organic Framework as a Nanoprobe for pH Sensitive Targeted Anticancer Drug Delivery[J]. Appl Mater Interfaces,2016,8(26):16573-16583.
[7]	Muniyandy S,Kesavan B,Gomathinayagam M,et al. Ultrasonically Controlled Release and Targeted Delivery of Diclofenac Sodium via Gelatin Magnetic Microspheres[J]. Int J Pharm,2004,283(1/2):71-82.
[8]	Issadore D,Park Y I,Shao H,et al. Magnetic Sensing Technology for Molecular Analyses[J]. Lab Chip,2014,14(14):2385-2397.
[9]	Pallab P,Jyotsnendu G,Finn R,et al. Targeted Temperature Sensitive Magnetic Liposomes for Thermo-chemotherapy[J]. J Controlled Release,2010,142(1):108-121.
[10]	Lee S,Zhu X,Wang Y J,et al. Ultrasound, pH, and Magnetically Responsive Crown-Ether-Coated Core/Shell Nanoparticles as Drug Encapsulation and Release Systems[J]. Appl Mater Interfaces,2013,5(5):1566-1574.
[11]	Wang H,Wang K,Tian B,et al. Preloading of Hydrophobic Anticancer Drug into Multifunctional Nanocarrier for Multimodal Imaging, NIR-Responsive Drug Release, and Synergistic Therapy[J]. Small,2016,12(46):6388-6397.
[12]	Gou M,Li S,Zhang L,et al. Facile One-Pot Synthesis of Carbon/Calcium Phosphate/Fe3O4 Composite Nanoparticles for Simultaneous Imaging and pH/NIR-Responsive Drug Delivery[J]. Chem Commun,2016,52(74):11068-11071.
[13]	KSwain A,Pradhan L,Bahadur D,et al. Polymer Stabilized Fe3O4 Graphene as an Amphiphilic Drug Carrier for Thermo-Chemotherapy of Cancer[J]. Appl Mater Interfaces,2015,7(15):8013-8022.
[14]	Zhao W,Cui B,Peng H X,et al. Novel Method to Investigate the Interaction Force Between Etoposide and APTES-Functionalized Fe3O4@nSiO2@mSiO2 Nanocarrier for Drug Loading and Release Processes[J]. Phys Chem C,2015,119(8):4379-4386.
[15]	Moorthy M S,Oh Y,Bharathiraja S,et al. Synthesis of Amine-polyglycidol Functionalised Fe3O4@SiO2 Nanocomposites for Magnetic Hyperthermia, pH-responsive Drug Delivery, and Bioimaging Applications[J]. RSC Adv,2016,6(113):110444-110453.
[16]	Liang W T,Yang C,Zhou D Y,et al. Phase-controlled Supramolecular Photochirogenesis in Cyclodextrin Nanosponges[J]. Chem Commun,2013,49(34):3510-3512.
[17]	Wei X Q,Liang W T,Wu W H,et al. Solvent- and Phase-Controlled Photochirogenesis. Enantiodifferentiating Photoisomerization of (Z)-Cyclooctene Sensitized by Cyclic Nigerosylnigerose-Based Nanosponges Crosslinked by Pyromellitate[J]. Org Biomol Chem,2015,13(10):2905-2912.
[18]	GONG Tao,ZHAO Meiling,LIANG Wenting,et al. Adsorption of Malachite Green by Linear Maltodextrin Supramolecular Polymer[J]. J Shanxi Univ(Nat Sci Ed),2017,40(2):316-323(in Chinese). 弓韬,赵美玲,梁文婷,等. 线性麦芽糊精超分子聚合物对孔雀石绿吸附性能研究[J]. 山西大学学报(自然科学版),2017,40(2):316-323.
[19]	Gong T,Zhou Y H,Sun L L,et al. Effective Adsorption of Phenolic Pollutants from Water Using β-Cyclodextrin Polymer Functionalized Fe3O4 Magnetic Nanoparticles[J]. RSC Adv,2016,6(84):80955-80963.
[20]	Yu S,Wu G,Gu X,et al. Magnetic and pH-sensitive Nanoparticles for Antitumor Drug Delivery[J]. Colloids Surf B,2013,103(1):15-22.
[21]	Sahoo B,Devi K S,Banerjee R,et al. Thermal and pH Responsive Polymer-Tethered Multifunctional Magnetic Nanoparticles for Targeted Delivery of Anticancer Drug[J]. Appl Mater Interfaces,2013,5(9):3884-3893.

Linear Maltodextrin Polymer Functionalized Fe₃O₄ Magnetic Nanoparticles as Drug Carriers

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