Synthesis and Properties of a Zn2+ Fluorescent Probe Based on Coumarins

doi:10.11944/j.issn.1000-0518.2018.05.170197

Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (5): 532-537.DOI: 10.11944/j.issn.1000-0518.2018.05.170197

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Synthesis and Properties of a Zn²⁺ Fluorescent Probe Based on Coumarins

SU Ce(),CHANG Kaishan,LI Siliang,LI Guanbin,ZHANG Hongbo,BAI Lingling

College of Petro-Chemical Engineering,Lanzhou University of Technology,Lanzhou 730050,China

Received:2017-06-05 Accepted:2017-11-09 Published:2018-04-23 Online:2018-04-23
Contact: SU Ce
Supported by:
Supported by the National Natural Science Foundation Project(No.21462025)

Abstract

Abstract:

A coumarin type fluorescent probe was synthesized from 1H-indole-3-carbohydrazide hydrazide and 8-formyl 7-hydroxy-4-methylcoumarin, which was obtained by Pechmann condensation of resorcinol and ethyl acetoacetate followed by formylation employing hexamethylenetetramine. The structure and fluorescence properties of this probe were characterized by nuclear magnetic resonance spectroscopy(NMR), mass spectrometry(MS), fluorescence emission spectrometer and UV-visible absorption spectrum. The probe coordinated with Zn²⁺ in 1∶1 ratio and led to high selectivity for the detection of Zn²⁺ with a detection limit at 3.6×10^-8 mol/L. These demonstrate potential application of the probe for the detection of Zn²⁺ in biological studies.

Key words: coumarin, fluorescent probe, zinc ion, indole hydrazide

SU Ce, CHANG Kaishan, LI Siliang, LI Guanbin, ZHANG Hongbo, BAI Lingling. Synthesis and Properties of a Zn²⁺ Fluorescent Probe Based on Coumarins[J]. Chinese Journal of Applied Chemistry, 2018, 35(5): 532-537.

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Synthesis and Properties of a Zn²⁺ Fluorescent Probe Based on Coumarins

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