Synthesis and Antioxidation Activity of 3-Amino-7,8-dimethoxycoumarin and Its Derivatives

doi:10.11944/j.issn.1000-0518.2020.12.200090

Chinese Journal of Applied Chemistry ›› 2020, Vol. 37 ›› Issue (12): 1420-1425.DOI: 10.11944/j.issn.1000-0518.2020.12.200090

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Synthesis and Antioxidation Activity of 3-Amino-7,8-dimethoxycoumarin and Its Derivatives

CHEN Lin^a*, MIN Man^b, LIN Jidi^a

^aCollege of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China;
^bGuangzhou Huibiao Testing Technology Center,Guangzhou 510670,China

Received:2020-03-25 Revised:2020-07-21 Accepted:2020-08-18 Published:2020-12-01 Online:2020-12-07
Contact: CHEN Lin, professor; Tel:020-39352141; E-mail:chenlin128@126.com; Research interests:fine organic synthesis and technology
Supported by:
Science and Technology Planning Project of Guangdong Province, China(No.2012b061700040) and the Medical Science and Technology Research Fund Project of Guangdong Province(No.201618171249486)

Abstract

Abstract: Eleven coumarin compounds with aromatic amide skeletons were synthesized. The antioxidant activities of the synthesized compounds were investigated by quenching 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulphonate) ammonium salt cationic radical (ABTS^+·) and hydroxyl radicals. The results show that the scavenging ability of compound 2b to DPPH radicals and hydroxyl radicals is beyond or close to that of the control vitamin C, while the antioxidant activity of derivatives 2a, 2b and 2c is better than that of the parent. Therefore, acylation is a promising way to improve the antioxidant capacity of 3-amino-7,8-dimethoxycoumarin, especially the scavenging capacity of hydroxyl radicals.

Key words: 3-amino-7,8-dimethoxycoumarins, synthesis, antioxidation

CLC Number:

O626

CHEN Lin, MIN Man, LIN Jidi. Synthesis and Antioxidation Activity of 3-Amino-7,8-dimethoxycoumarin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, 2020, 37(12): 1420-1425.

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Synthesis and Antioxidation Activity of 3-Amino-7,8-dimethoxycoumarin and Its Derivatives

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