A Quinazolinone Derivative-based Fluorescent Probe for Hypochlorite Ion Recognition

doi:10.11944/j.issn.1000-0518.2017.12.170316

Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (12): 1462-1467.DOI: 10.11944/j.issn.1000-0518.2017.12.170316

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A Quinazolinone Derivative-based Fluorescent Probe for Hypochlorite Ion Recognition

JIANG Ya'nan,TANG Lijun(),BIAN Yanjiang,ZHONG Keli,HOU Shuhua

College of Chemistry and Chemical Engineering,Bohai University,Jinzhou,Liaoning 121013,China

Received:2017-09-04 Accepted:2017-09-28 Published:2017-12-04 Online:2017-12-04
Contact: TANG Lijun
Supported by:
Supported by the National Natural Science Foundation of China(No.21476029, No.U1608222), Program for Liaoning Excellent Talents in University(No.LR2015001)

Abstract

Abstract:

Hypochlorite(ClO^-) displays essential roles in human immune system, the detection of which has aroused extensive attention. Herein, a hydrazone type fluorescent probe(HEMQ) that containing quinazolinone skeleton was designed and synthesized, and the structure of HEMQ was characterized by ¹H NMR, ¹³C NMR, and HRMS analysis. In V(ethanol):V(water)=1:1(c(PBS)=0.02 mol/L, pH=8.7) solution, probe HEMQ exhibits rapid response and good selectivity toward ClO^- through distinct fluorescence quenching. HEMQ displays good sensitivity to ClO^- with a detection limit of 1.0×10^-4 mol/L. In addition, ClO^- can induce a color change from yellow to colorless of the probe solution, thus, probe HEMQ can act as a colorimetric and florescent dual-channel ClO^- probe.

Key words: quinazolinone, fluorescent probe, hypochlorite, recognition

JIANG Ya'nan, TANG Lijun, BIAN Yanjiang, ZHONG Keli, HOU Shuhua. A Quinazolinone Derivative-based Fluorescent Probe for Hypochlorite Ion Recognition[J]. Chinese Journal of Applied Chemistry, 2017, 34(12): 1462-1467.

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A Quinazolinone Derivative-based Fluorescent Probe for Hypochlorite Ion Recognition

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