Abstract:

Using isovanillin as the starting material, the lactone ring-opened taspine derivative(compound 8) was obtained via bromination, benzylation, oxidation, Ulmman reaction and catalytic hydrogenation. Based on this, we designed and synthesized two novel lactone ring-opened taspine coumarin ester fluorescent derivatives with substituted coumarin(compounds 9a and 9b). The structures of the target compounds were characterized by means of IR, 1H NMR and MS. The fluorescence and the anti-tumor activities of the target compounds were preliminarily examined.

Key words: taspine, coumarin, fluorescence, anti-tumor activity