Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (4): 685-693.DOI: 10.19894/j.issn.1000-0518.210580

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Nd3+ Sensitized Fluorescent Nanoprobes for Vascular Imaging in the Second Near Infrared Window

Song-Tao ZHANG1,2, Ying-Hui WANG1(), Hong-Jie ZHANG1,2()   

  1. 1.State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
    2.University of Chinese Academy of Sciences,Beijing 100049,China
    3.Department of Chemistry,Tsinghua University,Beijing 100084,China
  • Received:2021-12-28 Accepted:2022-03-08 Published:2022-04-01 Online:2022-04-19
  • Contact: Ying-Hui WANG,Hong-Jie ZHANG
  • Supported by:
    National Natural Science Foundation of China(52022094);the Youth Innovation Promotion Association of Chinese Academy of Sciences(2019232)


In recent years, in comparison to the light in the visible range (400~700 nm) and first near-infrared window (NIR-Ⅰ, 700~1000 nm), the light in the second near-infrared window (NIR-Ⅱ, 1000~1700 nm) possess the merits of the lowest optical scattering and absorption in the bio-tissue. So NIR-Ⅱ fluorescence imaging with deeper tissue penetration depths, high spatiotemporal resolution and signal to noise ratio (SNR) plays an important role in the fields of angiography, lymphangiography and so on. Herein, Nd3+ sensitized fluorescent nanoprobe (U/DNPs, NaGdF4∶Yb(18% mole fraction),Ho(2%),Ce(30%)@NaGdF4,Nd(60%)@NaGdF4,Nd(10%)) with core-shell-shell is synthesized through high-temperature coprecipitation and epitaxial growth method. Under the irradiation of 808 nm, the NIR-Ⅱ fluorescence at 1056 nm and 1332 nm are obtained via down-conversion process for further vascular imaging. Furthermore, it can emit red upconversion fluorescence with high red to green (R/G) ratio (I647/I540= 22.6), possessing greatly potential application for photodynamic therapy. After successful modification of polyvinyl pyrrolidone (PVP) via ligand-exchange strategy, the U/DNPs-PVP nanomaterials possess excellent solubility in water and good biocompatibility, and can achieve the NIR-Ⅱ fluorescence vessels imaging with spatial resolution of 336.3 μm in vivo.

Key words: Rare earth ions, Second near-infrared window, Vascular imaging, Fluorescence imaging

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