Chinese Journal of Applied Chemistry ›› 2023, Vol. 40 ›› Issue (4): 509-517.DOI: 10.19894/j.issn.1000-0518.220340

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Synthesis of Oil-soluble Carbon Quantum Dots by Pyrolysis Method for the Detection of Oxytetracycline

Yue-Xia ZHANG, Xiao-Peng FAN, Yu-Juan CAO, Xin-Tong YANG, Zhong-Ping LI, Zhen-Hua YANG(), Chuan DONG   

  1. Institute of Environmental Science,Shanxi University,Taiyuan 030006,China
  • Received:2022-10-19 Accepted:2023-02-20 Published:2023-04-01 Online:2023-04-17
  • Contact: Zhen-Hua YANG
  • About
  • Supported by:
    Shanxi Scholarship Council of China(2020-002)


Novel oil-soluble fluorescent carbon quantum dots (o-CDs) are prepared by pyrolysis with citric acid, glutathione and oleamine as raw materials. The o-CDs have good photochemical properties and optical stability. The maximum excitation wavelength and emission wavelengths are located at 375 and 440 nm, respectively, and the fluorescence quantum yield is 0.48. A fluorescence sensor with high sensitivity and selectivity for detection of oxytetracycline is established based on the fluorescence quenching effect. The o-CDs based fluorescence sensor exhibits a good linear relationship between the relative fluorescence intensity and the concentration of oxytetracycline (0.77~16.12 μg/mL) with the detection limit of 0.14 μg/mL. Furthermore, the sensor has the potential to determine oxytetracycline in milk samples. The spiked recoveries are in the range of 97.13%~104.18%, and the RSD value is less than 5%. The accuracy of the method is verified. The o-CDs is capable of monitoring oxytetracycline in food industry.

Key words: Pyrolysis method, Oil-soluble carbon dots, Oxytetracycline, Fluorescence quenching

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