Chinese Journal of Applied Chemistry

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A Study on the interaction between CdTe/CdS Quantum Dots with Mitomycin C and its Analytical Application

LI Pingping, YIN Pengfei, GONG Huiping, LIU Zhengqing, WANG Xiaodan, HE Youqiu*   

  1. (School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715,China)
  • Received:2011-07-22 Revised:2011-08-31 Online:2012-06-10 Published:2012-06-10
  • Contact: Youqiu

Abstract: Tiopronin(TP) capped with CdTe/CdS quantum dots(TP-CdTe/CdS QDs) was synthesized in aqueous solution. The paper utilized ultraviolet-visible(UV-Vis) absorption spectra and fluorescence spectrometry to study the interactions between TP-CdTe/CdS QDs and mitomycin C(MMC). With the optimum reaction conditions which was found to be at pH=7.6 with tris-HCl buffer solution, the quenched fluorescence intensity of TP-CdTe/CdS QDs was linearly proportional with the concentration of MMC, correlation coefficient r=0.9991, and the detection limits were in the range of 4.7×10-9~1.2×10-8 g/mL, and the detection limit(3σ) for MMC was 1.4×10-8 g/mL. The quantitative determination of MMC is quick, simple and convenient. This method has been applied to the determination of MMC in urine samples with satisfactory results.

Key words: CdTe/CdS QDs, UV-vis, Fluorescence quenching method, Mitomycin C

CLC Number: