Abstract: The mercaptoacetic acid(TGA) stabilized core-shell CdTe/CdS quantum dots(TGA-CdTe/CdS QDs) were synthesized using as stabilizer. A new method for the determination of jatrorrhizine hydrochloride has been developed based on the quenching of the fluorescence of TGA-CdTe/CdS QDs at excitation wavelength of 340 nm. The paper utilized fluorescence spectrometry and ultraviolet-visible(UV-Vis) absorption spectra to study the interaction between TGA-CdTe/CdS QDs and jatrorrhizine hydrochloride（JH）. Under optimized conditions, in which at the pH value is 7.4 using tris-HCl buffer solution, the quenched fluorescence intensity of TGA-CdTe/CdS QDs was linearly proportional with a correlation coefficient r=0.9991, and the limits of detection were in the range of 0.011~10 mg/L and the detection limit for JH(3σ) was 3.3×10-3 mg/L. JH could be conveniently and quantitatively detemined using this new method.

Key words: Jatrorrhizine hydrochloride, core-shell CdTe/CdS quantum dots, UV-Vis, fluorescence quenching