Abstract:

AA simulating device for magnetic drug targeting and release in human body was fabricated by using peristaltic pump, NdFeB magnet, polyethylene pipe, water bath and glass tube. The device was used to test the magnetic drug targeting and release property of a model magnetic drug-carried particles Fe3O4@DFUR-LDH(DFUR: doxifluridine,LDH:layered double hydroxide). It is found that the retention of the Fe3O4@DFUR-LDH particles can be achieved to 85.3%, and it decreases as increasing the distance between the magnet and Fe3O4@DFUR-LDH particles in this device. Increasing the velocity of the release medium can also lead to the decrease of the retention of Fe3O4@DFUR-LDH particles. It also reveals that the drug release rate of Fe3O4@DFUR-LDH particles increases gradually as increasing the velocity of the releasing medium in this device. By modifying the pipe system, the situation when the drug was continuously consumed in the human body was also simulated. This device can not only simulate the magnetic targeting, but also analyze the drug release behavior of the magnetic drug-carried particles retained in a special site with the use of a magnetic field, thus providing an effective way to analyze the properties of magnetic drug-carried particles before submitting to the clinical study.

Key words: Magnetic drug targeting, Device design, Simulation, Drug release, Doxifluridine