A New Synthetic Route to 3,5-Diaminopyridine and 3,5-Dimethoxycarbonylamino-pyridine

doi:10.3724/SP.J.1095.2011.00065

Chinese Journal of Applied Chemistry ›› 2012, Vol. 29 ›› Issue (01): 80-83.DOI: 10.3724/SP.J.1095.2011.00065

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A New Synthetic Route to 3,5-Diaminopyridine and 3,5-Dimethoxycarbonylamino-pyridine

HU Bingcheng^*, LIANG Changyu, LU Ming, DAI Hongsheng , SUN Chengguo, XU Shichao

(School of Chemical Engineering,Nanjing University of Science & Technology,Nanjing 210094)

Received:2011-02-21 Revised:2011-04-08 Published:2012-01-10 Online:2012-01-10
About author:Changyu Liang Nanjing University of Science & Technology

Abstract

Abstract:

3,5-Diaminopyridine and 3,5-dimethoxycarbonylamino-pyridine were prepared from 3,5-dimethylpyridine in three steps including oxidation of methyl, amination and Hofmann degradation with the total yield of 64% and 68%, respectively. The reaction conditions of every step were studied and the intermediates and target compounds were characterized by 1H NMR, MS/MS, and IR. The reactions proceed under atmosphere pressure with mild reaction conditions, easy post treatment and high efficiency.

Key words: dimethylpyridine, Hofmann degradation, diaminopyridine, pyridinedicarbonylanmino, synthesis

CLC Number:

O629.9

HU Bingcheng*, LIANG Changyu, LU Ming, DAI Hongsheng , SUN Chengguo, XU Shichao. A New Synthetic Route to 3,5-Diaminopyridine and 3,5-Dimethoxycarbonylamino-pyridine[J]. Chinese Journal of Applied Chemistry, 2012, 29(01): 80-83.

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A New Synthetic Route to 3,5-Diaminopyridine and 3,5-Dimethoxycarbonylamino-pyridine

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