Chinese Journal of Applied Chemistry ›› 2012, Vol. 29 ›› Issue (01): 80-83.DOI: 10.3724/SP.J.1095.2011.00065

• Full Papers • Previous Articles     Next Articles

A New Synthetic Route to 3,5-Diaminopyridine and 3,5-Dimethoxycarbonylamino-pyridine

HU Bingcheng*, LIANG Changyu, LU Ming, DAI Hongsheng , SUN Chengguo, XU Shichao   

  1. (School of Chemical Engineering,Nanjing University of Science & Technology,Nanjing 210094)
  • Received:2011-02-21 Revised:2011-04-08 Published:2012-01-10 Online:2012-01-10
  • About author:Changyu Liang    Nanjing University of Science & Technology     


3,5-Diaminopyridine and 3,5-dimethoxycarbonylamino-pyridine were prepared from 3,5-dimethylpyridine in three steps including oxidation of methyl, amination and Hofmann degradation with the total yield of 64% and 68%, respectively. The reaction conditions of every step were studied and the intermediates and target compounds were characterized by 1H NMR, MS/MS, and IR. The reactions proceed under atmosphere pressure with mild reaction conditions, easy post treatment and high efficiency.

Key words: dimethylpyridine, Hofmann degradation, diaminopyridine, pyridinedicarbonylanmino, synthesis

CLC Number: