Synthesis of 3,4-Dihydropyrimidine-2(1H)-one Derivatives Using Phosphotungstic Acid Supported on Silica as Catalyst

doi:10.3724/SP.J.1095.2014.40046

Chinese Journal of Applied Chemistry

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Synthesis of 3,4-Dihydropyrimidine-2(1H)-one Derivatives Using Phosphotungstic Acid Supported on Silica as Catalyst

XU Yulin, GONG Wenpeng, YANG Shuijin^*

(College of Chemistry and Chemical Engineering,Hubei Collaborative Innovation Center for
Rare Metal Chemistry,Hubei Normal University,Huangshi 435002,China)

Received:2014-02-19 Revised:2014-04-26 Published:2014-09-04 Online:2014-09-04
Contact: Shui-Jin YANG
About author:Corresponding author: Prof. Dr. Shuijin Yang, Tel: 15629597607; E-mail: yangshuijin@163.com; Research direction: Inorganic functional materials.

Abstract

Abstract: 3,4-Dihydropy-rimidine-2(1H)-one was synthesized from substituted benzaldehyde, ethylacetoacetate and urea using phosphotungstic acid（H3PW12O40） supported on SiO2 as a novel eco-friendly catalyst prepared by a sol-gel technique. The influences of the molar ratio of reactants, reaction temperature, catalyst loading and reaction time were discussed. H3PW12O40/SiO2 is a good catalyst for the synthesis of 3,4-dihydropy-rimidine-2(1H)-one with the yield of 73.1%~88.4% under optimized conditions. The catalyst was characterized by IR, XRD and SEM, and the products were characterized by 1H NMR, IR and MS.

Key words: sol-gel technique, phosphotungstic acid/silica, catalysis, synthesis, dihydro-pyrimidine-2(1H)-one

CLC Number:

XU Yulin, GONG Wenpeng, YANG Shuijin*. Synthesis of 3,4-Dihydropyrimidine-2(1H)-one Derivatives Using Phosphotungstic Acid Supported on Silica as Catalyst[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.40046.

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Synthesis of 3,4-Dihydropyrimidine-2(1H)-one Derivatives Using Phosphotungstic Acid Supported on Silica as Catalyst

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