Research Progress on Amino Acid-Based Antimicrobial Polymers

doi:10.19894/j.issn.1000-0518.210065

Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (5): 559-571.DOI: 10.19894/j.issn.1000-0518.210065

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Research Progress on Amino Acid-Based Antimicrobial Polymers

LIU Hui^1,2, LIU Xiao^1,2, CAO Yuan-Qiao^1,2, LIU Ming¹, LIU Ya-Dong¹, HAN Miao-Miao^1*, JI Sheng-Xiang^1,2*

¹Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
²University of Science and Technology of China, Hefei 230026, China

Received:2021-02-08 Accepted:2021-03-09 Published:2021-05-01 Online:2021-07-01
Supported by:
National Natural Science Foundation of China(Nos.51773201, 51973212), the Joint Program of CAS-Jilin Province(No.2019SYHZ0002), the Bureau of Science and Technology of Changchun(No.19SS005) and the Department of Science and Technology of Jilin Province(No.20200301017RQ)

Abstract

Abstract: Antimicrobial peptides (AMPs) are short peptide molecules that are produced by organisms and can inhibit or kill bacteria or fungi through non-specific interactions. However, the lack of chemical and pharmacokinetic stability and high production cost limits the clinical applications of these AMPs. Amino acid-based polymers are widely studied as an effective alternative to AMPs. This review surveys the recent progress of amino acid-based polymers as antibacterial agents. The relationship between the polymer structure, starting from specific cationic amino acid residues to more specific characteristics such as hydrophobicity, secondary structure, topological structure and self-assembly behavior, and antibacterial activities is discussed. The optimized polymer can retain broad-spectrum antimicrobial activities, low toxicity, and excellent selectivity.

Key words: Amino acid-based polymers, Lysine, Arginine, Antimicrobial, Antibacterial, Toxicity

CLC Number:

O631

LIU Hui, LIU Xiao, CAO Yuan-Qiao, LIU Ming, LIU Ya-Dong, HAN Miao-Miao, JI Sheng-Xiang. Research Progress on Amino Acid-Based Antimicrobial Polymers[J]. Chinese Journal of Applied Chemistry, 2021, 38(5): 559-571.

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Research Progress on Amino Acid-Based Antimicrobial Polymers

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