Synthesis and Antibacterial Activities of Osthole Ester Derivatives

doi:10.19894/j.issn.1000-0518.200388

Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (8): 917-922.DOI: 10.19894/j.issn.1000-0518.200388

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Synthesis and Antibacterial Activities of Osthole Ester Derivatives

YANG Jia-Qiang^*,WU Xue-Jiao, ZHOU Xu-Rong, DENG Ling, YANG Hong

School of Pharmacy, Zunyi Medical University, Zunyi 563000, China

Received:2020-12-22 Revised:2021-04-15 Published:2021-08-01 Online:2021-10-01
Supported by:
Traditional Chinese Medicine Technology Department of Guizhou Province (No.QZYY[2018]085) and the Science and Technology of Zunyi City(No.HZ[2020]41)

Abstract

Abstract: To find antibacterial compounds, a series of osthole ester derivatives was synthesized through three steps of oxidation, reduction, condensation reactions using osthole as the starting material. The antibacterial activities of these products were evaluated for S.aureus, E.coli and meticillin-resistant Staphylococcus aureus (MRSA) by the agar dilution method. The test results show that these derivatives have different degrees of antibacterial activities. Among them, compound Ⅲi has the most significant antibacterial activities against S.aureus and MRSA and the minimum inhibitory concentration (MIC) values are 16 mg/L, and its anti-MRSA activity is more prominent. It is worthy of further structural optimization and study.

Key words: Osthole, Ester derivative, Antibacterial activity

CLC Number:

O629

YANG Jia-Qiang,WU Xue-Jiao, ZHOU Xu-Rong, DENG Ling, YANG Hong. Synthesis and Antibacterial Activities of Osthole Ester Derivatives[J]. Chinese Journal of Applied Chemistry, 2021, 38(8): 917-922.

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Synthesis and Antibacterial Activities of Osthole Ester Derivatives

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