Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (5): 542-546.DOI: 10.11944/j.issn.1000-0518.2015.05.140302

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Microwave Synthesis and Antibacterial Activity of Novel Asymmetric Porphyrin Matal Complexes from Substituted Piperonal

ZHAO Shengfanga, *, CHEN Nianyoua, ZHANG Hanmeia, ZHANG Jinga, LI Zaoyingb   

  1. aHubei Key Laboratory for Processing and Application of Catalytic Materials, College of Chemical Engineering, Huanggang Normal University, Huanggang, Hubei 438000, China
    bCollege of Chemical and Molecular Sciences, Wuhan University, Wuhan 430072, China
  • Received:2014-09-01 Revised:2014-10-29 Accepted:2014-11-20 Published:2015-05-05 Online:2015-05-05
  • Contact: ZHAO Shengfang
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21307038);Natural Science Foundation of Hubei Province(No.2013CFC056)

Abstract:

Zn(Ⅱ), Co(Ⅱ) and Mn(Ⅱ) complexes of 5-(2-nitro-4, 5-methylenedioxy)phenyl-10, 15, 20- triphenyl-porphyrin and 5-(2-nitro-4, 5-methylenedioxy) phenyl-10, 15, 20-tri(p-chlorophenyl)-porphyrin were synthesized by microwave irradiation. Their structures were characterized by UV-Vis, IR, fluoresence spectroscopies. The bactericidal activities of these metal compounds on Escherichia coli aureu(Ec) and Staphylococcusaureu(Sa) were studied with the inhibition ring test. These complexes show photosensitive antibacterial activities against these two bacteria. The Co(Ⅱ) complexes have obvious bacteriostatic activities against Ec and Sa at the concentration of 0.32 mmol/L and 0.02 mmol/L, respectively, and some bacteriostatic effects. The Zn(Ⅱ) and Co(Ⅱ) complexes have moderate antibacterial effects at 0.16~0.32 mmol/L. The order of the antibacterial activity of these complexes is Por(Co)>Por(Mn)≈Por(Zn). The bacteriostatic effects of the complexes on Ec are 10%~20% higher than those on Sa.

 

Key words: asymmetrical porphyrin, metal complex, microwave synthesis, characterization, antibacterial activity

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