Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (1): 51-59.DOI: 10.19894/j.issn.1000-0518.200214

• Full Papers • Previous Articles     Next Articles

Preparation of Imidazolium Salt-based Poly(ionic liquids) Antibacterial Agent and Its Application in Hydrogel Dressing

ZHOU Chao*, SHENG Cheng-Ju, WEN Lin-Lin   

  1. Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China
  • Received:2020-07-17 Revised:2020-10-22 Online:2021-01-01 Published:2021-02-01
  • Supported by:
    Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No.19KJD430001) and the Natural Science Foundation of Jiangsu Province (No.BK20180963)

Abstract: Skin wound infections seriously threaten the lives of patients. Although traditional antibacterial hydrogels containing biocides such as silver ions or small molecule antibiotics have a broad-spectrum bactericidal effect and are used as wound dressings, the biological toxicity of silver ions and drug resistance of small molecule antibiotics cannot meet the requirements of long-term clinical application. The imidazolium salt-based poly(ionic liquids) are novel polymer antibacterial agents that exhibit strong antibacterial property, owing to their strong positive charge effect and hydrophobic polymer segments. In this study, imidazolium salt-based poly(ionic liquids) contained furan functional groups as strong antibacterial agents were synthesized by Radziszewski reaction. Then, the imidazolium salt-based poly(ionic liquids) were compounded with hyaluronic acid/polyethylene glycol by Diels-Alder “click” reaction to prepare antibacterial hydrogels. The in vitro assays show that the antibacterial hydrogels containing imidazolium salt-based poly(ionic liquids) can quickly kill bacteria and also have low toxicity towards human skin fibroblasts. This kind of hydrogels can be applied in various biomedical fields.

Key words: Antibacterial polymers, Poly(ionic liquids), “Click” reaction, Cytotoxicity, Hydrogel dressin

CLC Number: