Progress of the Construction and Application of the Polymer-based Vaccine Delivery System

doi:10.19894/j.issn.1000-0518.210055

Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (5): 582-591.DOI: 10.19894/j.issn.1000-0518.210055

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Progress of the Construction and Application of the Polymer-based Vaccine Delivery System

PAN Yong^1,2, QI Yan-Xin^2*, LI Xiao-Yuan¹, HUANG Yu-Bin^1*

¹Department of Chemistry, Northeast Normal University, Changchun 130024, China
²State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received:2021-01-30 Accepted:2021-03-05 Published:2021-05-01 Online:2021-07-01
Supported by:
National Natural Science Foundation of China (Nos.51673188, 51903233, 21975246)

Abstract

Abstract: Vaccine is a biological product developed by humans to resist the invasion of the pathogens, which can control and prevent the infectious diseases effectively. However, some existing vaccines have poor immunogenicity due to their component and structural defects, which cannot induce the immune response well. As a consequence, using the suitable carriers and adjuvant to construct an effective vaccine delivery system through reasonable design has received the attention of the academic and industrial circles. This article reviews the recent progress of existing vaccine delivery systems, explains the shortcomings of existing vaccine delivery systems and the advantages of polymer vaccine delivery systems. Besides, the application of the polymer-based vaccine delivery system in various types of vaccines is systematically explained in terms of natural polymer and synthetic polymer. Subsequently, the advantages of the application prospects of the polymer-based vaccine systems in the development of new immune methods are discussed. Finally, the future trend of the polymer-based vaccine systems is prospected.

Key words: Polymer, Vaccine, Delivery system, Carrier, Adjuvant

CLC Number:

O631

PAN Yong, QI Yan-Xin, LI Xiao-Yuan, HUANG Yu-Bin. Progress of the Construction and Application of the Polymer-based Vaccine Delivery System[J]. Chinese Journal of Applied Chemistry, 2021, 38(5): 582-591.

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Progress of the Construction and Application of the Polymer-based Vaccine Delivery System

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