多贝斯在石墨烯修饰玻碳电极上的电化学行为及其测定

doi:10.3724/SP.J.1095.2014.30481

摘要/Abstract

摘要： 制备了石墨烯修饰玻碳电极（GN/GCE）。在0.05 mol/L H2SO4溶液中，用循环伏安法研究了多贝斯在GN/GCE上的电化学行为。结果表明，GN/GCE对多贝斯的氧化还原反应有明显的电催化作用。建立了测定多贝斯的新方法，用微分脉冲伏安法测得多贝斯的氧化峰电流与其浓度在2.0×10-9~1.2×10-6 mol/L范围内呈线性关系，检出限为1.0×10-9 mol/L(S/N=3)。该法可用于胶囊中多贝斯的测定，修饰电极有较好的稳定性和重新性。

关键词: 多贝斯, 石墨烯, 修饰电极, 电催化

Abstract: A graphene modified glassy carbon electrode(GN/GCE) was prepared. The electrochemical behavior of calcium dobesilate on the modified electrode was investigated in 0.05 mol/L H2SO4 by cyclic voltammetry. The GN/GCE shows an obvious electrocatalytic activity toward the redox reaction of calcium dobesilate and a new method for the determination of calcium dobesilate is established. On differential pulse voltammetry curves, a linear dependence of oxidation current versus calcium dobesilate concentration is obtained in the range of 2.0×10-9~1.2×10-6 mol/L, with a detection limit of 1.0×10-9 mol/L(S/N=3). The proposed method was applied to determine calcium dobesilate in capsule. The modified electrode shows excellent stability and reproducibility.

Key words: calcium dobesilate, graphene, modified electrode, electrocatalysis

中图分类号:

O655

张亚, 杜芳艳, 郑建斌. 多贝斯在石墨烯修饰玻碳电极上的电化学行为及其测定[J]. 应用化学, DOI: 10.3724/SP.J.1095.2014.30481.

ZHANG Ya1*, DU Fangyan1, ZHENG Jianbin2. Electrochemical Behavior and Determination of Calcium Dobesilate at Graphene Modified Glassy Carbon Electrode[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30481.

参考文献

[1] Zivanovic L,Zecevic M,Markovic S,et al. Validation of Liquid Chromatographic Method for Analysis of Lidocaine Hydrochloride, Dexamethasone Acetate, Calcium Dobesilate, Buthylhydroxyanisol and Degradation Product Hydroquinone in Suppositories and Ointment[J]. J Chromatogr A,2005,1088(4):182-186.

[2] WEI Yongfeng,MA Dongmei,LANG Huiyun,et al. Determination of Doxium by Flow Injection Analysis with On-line Redox and Coloration Reaction[J]. Chinese J Anal Chem,2004,32(10):1375-1377(in Chinese).

魏永锋,马冬梅,郎惠云,等. 在线氧化还原流动注射分光光度法测定多贝斯[J]. 分析化学，2004,32(10):1375-1377.

[3] Kracmar J,Kracmavova J,Kovarova A,et al. UV Spertrophotometry in Drug Control[J]. Pharmazie,1988,43(7):173-178.

[4] WANG Haitao,DONG Fating,LANG Huiyun. Determination of Calcium Dobesilate Using Flow Injection Inhibitory Chemiluminescence[J]. Chinese J Anal Lab,2002,21(3):67-69(in Chinese).

汪海涛,董发昕,郎惠云. 流动注射-抑制化学发光测定多贝斯的方法研究[J]. 分析试验室,2002,21(3):67-69.

[5] Song J F,Chen J Q. Flow-injection Biamperometric Direct Determination of Calcium Dobesilate in Irreversible Couple System[J]. J Pharm Biomed Anal,2003,33(9):789-796.

[6] ZHANG Ya,ZHANG Zhifang. Determination of Calcium Dobesilate at Multi-wall Carbon Nanotube Modified Glassy Carbon Electrode[J]. Phys Test Chem Anal Part B:Cheml Anal,2009,45(11):1296-1298(in Chinese).

张亚,张智芳. 多壁碳纳米管修饰玻碳电极测定多贝斯[J]. 理化检验-化学分册,2009,45(11):1296-1298.

[7] ZHANG Ya,DU Fangyan,WEI Lele. Eelectrochemical Behavior of Calcium Dobesilate at a Gold Nanoparticles Modified Glassy Carbon Electrode and Its Determination[J]. Chinese J Anal Lab,2011,30(3):50-53(in Chinese).

张亚，杜芳艳，魏乐乐. 多贝斯在纳米金修饰玻碳电极上的电化学行为与测定[J]. 分析试验室,2011,30(3):50-53.

[8] Song Z H,Yue Q L,Wang C N. Flow Injection Chemiluninescence for Detecting Pictogram Amounts of Dobesilate in Human Urine[J]. Spectrochim Acta Part A,2004,60(12):2377-2382.

[9] Geim A K，Novoselov K S. The Rise of Graphene[J]. Nat Mater，2007，6(3):183-191.

[10] Shao Y，Wang J，Wu H，et al. Graphene Based Electrochemical Sensors and Biosensors[J]. Electroanalysis,2010,22(10):1027-1036.

[11] HE Chunlan,LIU Chenglun,XIE Taiping,et al. Preparation of Graphene and Electrocatalysis Oxidation of p-Hydroquinone at Graphene Modified Electrode[J]. Chem J Chinese Univ,2012,33(6):1290-1294(in Chinese).

何春兰，刘成伦，谢太平,等. 石墨烯的制备及石墨烯修饰电极对p-苯二酚的催化氧化[J]. 高等学校化学学报，2012，33(6)：1290-1294.

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