中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (10): 1165-1171.DOI: 10.3724/SP.J.1095.2010.90820

• 研究论文 • 上一篇    下一篇

三唑硫酮氨席夫碱吗啡亚甲胺的超声辐射合成及其生物活性

郑玉国,薛伟*,魏学   

  1. (贵州大学精细化工研究开发中心，教育部绿色农药和农业生物工程重点实验室 贵阳 550025)
  • 收稿日期:2009-12-07 修回日期:2010-02-20 出版日期:2010-10-10 发布日期:2010-10-10
  • 通讯作者: 薛伟，男，副教授; E-mail:wxue@gzu.edu.cn; 研究方向：新农药的创制
  • 基金资助:
    贵州省十一五农业攻关(20083061)和贵州省自然科学基金(20072010)资助项目

Ultrasonic Radiative Synthesis and Biological Activities of Morpholinomethylamino Containing 1,2,4-Triazole-5-thiones

ZHENG Yu-Guo, XUE Wei*, WEI Xue   

  1. (Key Laboratory of Green Pesticide and Bioengineering,Ministry of Education,Research and
    Development Center for Fine Chemicals,Guizhou University,Guiyang 550025)
  • Received:2009-12-07 Revised:2010-02-20 Published:2010-10-10 Online:2010-10-10

PDF

1338

被引次数

16 | 7

摘要：

在超声辐射和常规加热条件下合成了11个未见报道的1-(吗啡啉亚甲基)-3-(3,4,5-三甲氧基苯基)-4-(取代次甲亚胺基)-1,2,4-三唑-5-硫酮. 其结构经1H NMR、13C NMR、IR以及元素分析确证。初步生物活性测试结果表明, 在500 mg/L浓度下化合物对黄瓜花叶病毒(CMV)有一定抑制活性。

关键词: 超声波辐射, 三唑, 亚胺, 合成

Abstract:

Eleven novel 1-(morpholinomethyl)-3-(3,4,5-trimethoxyphenyl)-4-substitute deneamino-1,2,4-triazole-5-thiones were designed and synthesized by mean of an ultrasonic radiation method and a ordinary heating process. Their structures were characterized by 1H NMR, 13C NMR, IR and elemental analyses. Preliminary bioassay showed that some of them exhibit certain inactivities to Cucumber mosaic virus(CMV).

Key words: ultrasonic irradiation, triazole, Imines, synthesis

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