中华医学超声杂志

应用化学 ›› 1997, Vol. 0 ›› Issue (6): 98-100.

• 研究论文 • 上一篇    

呋喃甲酰基吡唑啉酮双席夫碱配合物的合成及其生物活性

李锦州1, 于文锦1, 杜晓燕2   

  1. 1. 哈尔滨师范大学化学系, 哈尔滨 150080;
    2. 哈尔滨医科大学公共卫生学院, 哈尔滨
  • 收稿日期:1997-06-16 修回日期:1997-09-09 出版日期:1997-12-10 发布日期:1997-12-10
  • 基金资助:
    黑龙江省自然科学基金

Synthesis, Characterization and Bioactivity of Bis-Schiff Base Complexes of Furoylpyrazolone

Li Jinzhou1, Yu Wenjin1, Du Xiaoyan2   

  1. 1. Department of Chemistry, Harbin Normal University, Harbin 150080;
    2. Institute of Public Health, Harbin Medical University, Harbin
  • Received:1997-06-16 Revised:1997-09-09 Published:1997-12-10 Online:1997-12-10

PDF

759

被引次数

47 | 7

摘要： 由于酰基吡唑啉酮配合物可提供萃取过程结构信息, 具有抗菌、抗病毒活性, 并可作为激光工作物质和核磁位移试剂[1]. 我们曾报道杂环酰基吡唑啉酮配合物的研究[2], 但关于呋喃甲酰基吡唑啉酮双席夫碱配合物的研究尚未见报道。

关键词: 酰基吡唑啉酮, 双席夫碱, 配合物, 合成, 生物活性

Abstract: Five novel bis schiff base complexes M(PMαFP)2en have been synthesized, where(HPMαFP)2en=N,N-bis[(1-phenyl-3-methyl-5-oxo-4 pyrazolinyl)α-furylmethylidyne]ethylenediimine, M=Cu(Ⅱ), Ni(Ⅱ), Co(Ⅱ), Pd(Ⅱ), Pt(Ⅱ). They were characterized by elemental analysis, IR, UV-vis, 1H NMR, 13C NMR, magnetic moment and molar conductance measurements. The results showed that the complexes are all of quadricoordinate square-planar geometry. The antibacterial experiment indicated that they have high antibacterial activities against S. aureus, B. subtillis, E. coli, E. carotovora and C. flaccumfaciens.

Key words: acylpyrazolone, bis-schiff base, complex, synthesis, bioactivity

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